K07H8.2 SLC41A/MgtE integral membrane domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: K07H8.2
Official Full Name: SLC41A/MgtE integral membrane domain-containing protein
Primary source: WormBase:WBGene00019504
Locus tag: CELE_K07H8.2
See related: AllianceGenome:WB:WBGene00019504
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable monoatomic cation transmembrane transporter activity. Predicted to be involved in monoatomic cation transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in intestine. Human ortholog(s) of this gene implicated in nephronophthisis. Orthologous to several human genes including SLC41A1 (solute carrier family 41 member 1) and SLC41A2 (solute carrier family 41 member 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See K07H8.2 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 6

Sequence:: Chromosome: IV; NC_003282.8 (8291583..8294590)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

K07H8.3 (e-PCR)
- UniSTS:316022

K07H8.2 (e-PCR)
- UniSTS:311461

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables monoatomic cation transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in monoatomic cation transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic cation transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: SLC41A/MgtE integral membrane domain-containing protein

NP_001370706.1

Confirmed by transcript evidence

NP_001379928.1

Confirmed by transcript evidence

NP_501394.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

8291583..8294590

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001383140.2 → NP_001370706.1 SLC41A/MgtE integral membrane domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

O45182

Conserved Domains (1) summary

pfam01769
Location:344 → 479

MgtE; Divalent cation transporter
NM_068993.7 → NP_501394.1 SLC41A/MgtE integral membrane domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_501394.1

Status: REVIEWED

UniProtKB/TrEMBL

Q965K0

Conserved Domains (1) summary

pfam01769
Location:127 → 258

MgtE; Divalent cation transporter
NM_001392347.1 → NP_001379928.1 SLC41A/MgtE integral membrane domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q5W612

Conserved Domains (1) summary

pfam01769
Location:53 → 185

MgtE; Divalent cation transporter