wrk-1 Ig-like domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: wrk-1
Official Full Name: Ig-like domain-containing protein
Primary source: WormBase:WBGene00006942
Locus tag: CELE_F41D9.3
See related: AllianceGenome:WB:WBGene00006942
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable axon guidance receptor activity. Predicted to be involved in homophilic cell adhesion via plasma membrane adhesion molecules and synapse organization. Predicted to be located in cytoplasm. Predicted to be active in axon; neuronal cell body; and plasma membrane. Is expressed in several structures, including coelomocyte; excretory gland cell; hermaphrodite distal tip cell; interfacial epithelial cell; and neurons. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See wrk-1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 10

Sequence:: Chromosome: X; NC_003284.9 (8387442..8392589, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

wrk-1 and rig-5 control pioneer and follower axon navigation in the ventral nerve cord of Caenorhabditis elegans in a nid-1 mutant background.
Title: wrk-1 and rig-5 control pioneer and follower axon navigation in the ventral nerve cord of Caenorhabditis elegans in a nid-1 mutant background.
WRK-1 acts in eMNs to prevent follower axons from inappropriately crossing the ventral midline.
Title: A novel Eph receptor-interacting IgSF protein provides C. elegans motoneurons with midline guidepost function.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F41D9.3 (e-PCR)
- UniSTS:320069

STS6-155 (e-PCR)
- UniSTS:242536

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables axon guidance receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in axon guidance	IEA Inferred from Electronic Annotation more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
involved_in synapse organization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Ig-like domain-containing protein

NP_001024647.1

Confirmed by transcript evidence

NP_001024648.1

Confirmed by transcript evidence

NP_001024649.1

Confirmed by transcript evidence

NP_001024651.1

Confirmed by transcript evidence

NP_001360746.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

8387442..8392589 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001029476.4 → NP_001024647.1 Ig-like domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024647.1

Status: REVIEWED

UniProtKB/TrEMBL

H2KZN8, Q8WR44

Conserved Domains (3) summary

cd00096
Location:229 → 302

Ig; Immunoglobulin domain

smart00408
Location:134 → 194

IGc2; Immunoglobulin C-2 Type

smart00410
Location:25 → 113

IG_like; Immunoglobulin like
NM_001373391.4 → NP_001360746.1 Ig-like domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A4V0ING2, Q8WR43

Conserved Domains (3) summary

smart00408
Location:134 → 196

IGc2; Immunoglobulin C-2 Type

smart00409
Location:25 → 113

IG; Immunoglobulin

cl11960
Location:229 → 313

Ig; Immunoglobulin domain
NM_001029480.6 → NP_001024651.1 Ig-like domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024651.1

Status: REVIEWED

UniProtKB/TrEMBL

Q5WRR1, Q8WR43

Conserved Domains (3) summary

cd00096
Location:245 → 318

Ig; Immunoglobulin domain

smart00408
Location:142 → 202

IGc2; Immunoglobulin C-2 Type

smart00410
Location:25 → 113

IG_like; Immunoglobulin like
NM_001029477.6 → NP_001024648.1 Ig-like domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024648.1

Status: REVIEWED

UniProtKB/TrEMBL

H2KZN9, Q8WR43

Conserved Domains (3) summary

cd00096
Location:237 → 310

Ig; Immunoglobulin domain

smart00408
Location:134 → 194

IGc2; Immunoglobulin C-2 Type

smart00410
Location:25 → 113

IG_like; Immunoglobulin like
NM_001029478.5 → NP_001024649.1 Ig-like domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024649.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8MPV0, Q8WR42

Conserved Domains (2) summary

smart00408
Location:134 → 194

IGc2; Immunoglobulin C-2 Type

smart00410
Location:25 → 113

IG_like; Immunoglobulin like