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    Y92H12BL.1 TRAM domain-containing protein;Threonylcarbamoyladenosine tRNA methylthiotransferase [ Caenorhabditis elegans ]

    Gene ID: 190786, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Y92H12BL.1
    Official Full Name
    TRAM domain-containing protein;Threonylcarbamoyladenosine tRNA methylthiotransferase
    Primary source
    WormBase:WBGene00022363
    Locus tag
    CELE_Y92H12BL.1
    See related
    AllianceGenome:WB:WBGene00022363
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable N6-threonylcarbomyladenosine methylthiotransferase activity. Predicted to be involved in tRNA methylthiolation. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in diabetes mellitus; diabetic retinopathy; gestational diabetes; and type 2 diabetes mellitus. Orthologous to human CDKAL1 (CDK5 regulatory subunit associated protein 1 like 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See Y92H12BL.1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    5
    Sequence:
    Chromosome: I; NC_003279.8 (1348503..1359643)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Peptidase M24 domain-containing protein;Xaa-Pro dipeptidase Neighboring gene Small ubiquitin-related modifier Neighboring gene diphosphoinositol-polyphosphate diphosphatase Neighboring gene Transposase Neighboring gene Rho-GAP domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables N6-threonylcarbomyladenosine methylthiotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N6-threonylcarbomyladenosine methylthiotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in tRNA methylthiolation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA methylthiolation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    TRAM domain-containing protein;Threonylcarbamoyladenosine tRNA methylthiotransferase
    NP_001293428.1
    • Confirmed by transcript evidence
    NP_740783.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      1348503..1359643
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170800.4 → NP_740783.2  Threonylcarbamoyladenosine tRNA methylthiotransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_740783.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MXQ7
      Conserved Domains (2) summary
      cd01335
      Location:68 → 273
      Radical_SAM; Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster. ...
      smart00729
      Location:67 → 268
      Elp3; Elongator protein 3, MiaB family, Radical SAM

    2. NM_001306499.3 → NP_001293428.1  TRAM domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293428.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      W6RR04
      Conserved Domains (1) summary
      COG0621
      Location:1 → 132
      MiaB; tRNA A37 methylthiotransferase MiaB [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MXQ7.2

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