ptrn-1 Patronin (microtubule-binding protein) homolog [Caenorhabditis elegans] - Gene

Summary

Go to the top of the page Help

Official Symbol: ptrn-1
Official Full Name: Patronin (microtubule-binding protein) homolog
Primary source: WormBase:WBGene00004121
Locus tag: CELE_F35B3.5
See related: AllianceGenome:WB:WBGene00004121
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables microtubule minus-end binding activity. Involved in cytoplasmic microtubule organization and nematode larval development. Located in microtubule minus-end. Is expressed in hypodermis; intestine; nervous system; and pharynx. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations. Orthologous to human CAMSAP1 (calmodulin regulated spectrin associated protein 1); CAMSAP2 (calmodulin regulated spectrin associated protein family member 2); and CAMSAP3 (calmodulin regulated spectrin associated protein family member 3). [provided by Alliance of Genome Resources, Dec 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See ptrn-1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 22

Sequence:: Chromosome: X; NC_003284.9 (17021820..17030219, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PTRN-1 CH domain is required to stimulate CYK-1 to facilitate actin dynamics during endocytic recycling.
Title: PTRN-1/CAMSAP promotes CYK-1/formin-dependent actin polymerization during endocytic recycling.
DAPK-1 and PTRN-1 physically interact in co-immunoprecipitation experiments, and DAPK-1 itself undergoes microtubule-dependent transport.
Title: DAPK interacts with Patronin and the microtubule cytoskeleton in epidermal development and wound repair.
These results show that NOCA-1 acts with gamma-tubulin to assemble non-centrosomal arrays in multiple tissues and highlight functional overlap between the ninein and Patronin protein families.
Title: NOCA-1 functions with γ-tubulin and in parallel to Patronin to assemble non-centrosomal microtubule arrays in C. elegans.
Propose a model whereby minus-end microtubule stabilization mediated by a functional PTRN-1 is necessary for morphological maintenance of neurons in C.elegans.
Title: The Caenorhabditis elegans microtubule minus-end binding homolog PTRN-1 stabilizes synapses and neurites.
Suggest that PTRN-1 represents an important mechanism for promoting microtubule stability in neurons.
Title: PTRN-1, a microtubule minus end-binding CAMSAP homolog, promotes microtubule function in Caenorhabditis elegans neurons.
PTRN-1 and DLK-1 function together to promote axonal regrowth.
Title: The microtubule minus-end-binding protein patronin/PTRN-1 is required for axon regeneration in C. elegans.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

F35B3.5 (e-PCR)
- UniSTS:310113

F35B3.6 (e-PCR)
- UniSTS:310114

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule minus-end binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule minus-end binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cytoplasmic microtubule organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytoplasmic microtubule organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of microtubule depolymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in nematode larval development	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in microtubule minus-end	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in sarcolemma	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: Patronin (microtubule-binding protein) homolog

NP_001294829.1

Confirmed by transcript evidence

NP_001294846.1

Partially confirmed by transcript evidence

NP_001294847.1

Confirmed by transcript evidence

NP_510751.4

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

17021820..17030219 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001307917.4 → NP_001294846.1 Patronin (microtubule-binding protein) homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001294846.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q966J8, U4PAZ9, U4PLF6, W6SB68

Conserved Domains (3) summary

smart01051
Location:972 → 1100

CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated

pfam11971
Location:188 → 270

CAMSAP_CH; CAMSAP CH domain

cl23720
Location:854 → 938

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
NM_078350.10 → NP_510751.4 Patronin (microtubule-binding protein) homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_510751.4

Status: REVIEWED

UniProtKB/Swiss-Prot

U4PAZ9

Conserved Domains (3) summary

smart01051
Location:970 → 1098

CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated

pfam11971
Location:188 → 270

CAMSAP_CH; CAMSAP CH domain

cl23720
Location:852 → 936

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
NM_001307900.4 → NP_001294829.1 Patronin (microtubule-binding protein) homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001294829.1

Status: REVIEWED

UniProtKB/Swiss-Prot

U4PAZ9

Conserved Domains (2) summary

smart01051
Location:457 → 585

CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated

cl23720
Location:339 → 423

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
NM_001307918.4 → NP_001294847.1 Patronin (microtubule-binding protein) homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001294847.1

Status: REVIEWED

UniProtKB/Swiss-Prot

U4PAZ9

Conserved Domains (1) summary

smart01051
Location:246 → 374

CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated