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    F53A10.2 Rap-GAP domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 173502, updated on 9-Dec-2024

    Summary

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    Official Symbol
    F53A10.2
    Official Full Name
    Rap-GAP domain-containing protein
    Primary source
    WormBase:WBGene00018734
    Locus tag
    CELE_F53A10.2
    See related
    AllianceGenome:WB:WBGene00018734
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in regulation of small GTPase mediated signal transduction. Predicted to be active in cytoplasm. Is expressed in intestine; neurons; and seam cell. Orthologous to human RAP1GAP (RAP1 GTPase activating protein) and RAP1GAP2 (RAP1 GTPase activating protein 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See F53A10.2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    13
    Sequence:
    Chromosome: II; NC_003280.10 (1197374..1230782)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Zinc metalloproteinase nas-27 Neighboring gene PAS domain-containing protein;Period protein homolog lin-42 Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Proteins interacting with Caenorhabditis elegans Galpha subunits. Cuppen E, et al. Comp Funct Genomics, 2003. PMID 18629017, Free PMC Article
    2. A genome-wide study of PDZ-domain interactions in C. elegans reveals a high frequency of non-canonical binding. Lenfant N, et al. BMC Genomics, 2010 Nov 26. PMID 21110867, Free PMC Article
    3. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
    4. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of small GTPase mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Rap-GAP domain-containing protein
    NP_001022190.1
    • Partially confirmed by transcript evidence
    NP_001309564.1
    • Confirmed by transcript evidence
    NP_001309565.1
    • Confirmed by transcript evidence
    NP_001309566.1
    • Confirmed by transcript evidence
    NP_001379965.1
    • Confirmed by transcript evidence
    NP_001379966.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      1197374..1230782
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001393000.1 → NP_001379965.1  Rap-GAP domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86RS9, Q965M4
      Conserved Domains (2) summary
      smart00390
      Location:79 → 101
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:313 → 492
      Rap_GAP; Rap/ran-GAP

    2. NM_001393001.1 → NP_001379966.1  Rap-GAP domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IA84
      Conserved Domains (1) summary
      pfam02145
      Location:1 → 126
      Rap_GAP; Rap/ran-GAP

    3. NM_001322701.3 → NP_001309564.1  Rap-GAP domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A131MBF2, Q86RS9
      Conserved Domains (2) summary
      smart00390
      Location:18 → 40
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:252 → 431
      Rap_GAP; Rap/ran-GAP

    4. NM_001027019.3 → NP_001022190.1  Rap-GAP domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022190.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2L055
      Conserved Domains (1) summary
      pfam02145
      Location:382 → 561
      Rap_GAP; Rap/ran-GAP

    5. NM_001322702.3 → NP_001309565.1  Rap-GAP domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A131MBM3, Q86RS9
      Conserved Domains (1) summary
      pfam02145
      Location:179 → 358
      Rap_GAP; Rap/ran-GAP

    6. NM_001322703.3 → NP_001309566.1  Rap-GAP domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A131MCP2
      Conserved Domains (1) summary
      pfam02145
      Location:157 → 336
      Rap_GAP; Rap/ran-GAP
    Nucleotide Protein
    Heading Accession and Version

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