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    hst-6 Heparan-sulfate 6-O-sulfotransferase [ Caenorhabditis elegans ]

    Gene ID: 189586, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hst-6
    Official Full Name
    Heparan-sulfate 6-O-sulfotransferase
    Primary source
    WormBase:WBGene00002031
    Locus tag
    CELE_Y34B4A.3
    See related
    AllianceGenome:WB:WBGene00002031
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable heparan sulfate 6-O-sulfotransferase activity. Involved in heparan sulfate proteoglycan biosynthetic process, enzymatic modification and regulation of growth. Predicted to be located in membrane. Is expressed in neurons. Human ortholog(s) of this gene implicated in Paganini-Miozzo syndrome and hypogonadotropic hypogonadism 15 with or without anosmia. Orthologous to several human genes including HS6ST1 (heparan sulfate 6-O-sulfotransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See hst-6 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    7
    Sequence:
    Chromosome: X; NC_003284.9 (5275561..5278519)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Rap guanine nucleotide exchange factor 1;Ras-GEF domain-containing protein Neighboring gene ncRNA Neighboring gene Rho-GAP domain-containing protein Neighboring gene ncRNA Neighboring gene UV radiation resistance-associated gene protein-like Neighboring gene tRNA Neighboring gene Vacuolar protein sorting-associated protein 41 homolog

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nematodes join the family of chondroitin sulfate-synthesizing organisms: Identification of an active chondroitin sulfotransferase in Caenorhabditis elegans. Dierker T, et al. Sci Rep, 2016 Oct 5. PMID 27703236, Free PMC Article
    2. Heparan sulphate sulphotransferase expression in mice and Caenorhabditis elegans. Turnbull J, et al. Biochem Soc Trans, 2003 Apr. PMID 12653634
    3. Genetic analysis of the heparan modification network in Caenorhabditis elegans. Townley RA, et al. J Biol Chem, 2011 May 13. PMID 21454666, Free PMC Article
    4. Direct visualization of specifically modified extracellular glycans in living animals. Attreed M, et al. Nat Methods, 2012 Apr 1. PMID 22466794, Free PMC Article
    5. Syndecan regulates cell migration and axon guidance in C. elegans. Rhiner C, et al. Development, 2005 Oct. PMID 16176946

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables heparan sulfate 6-O-sulfotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sulfotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in heparan sulfate proteoglycan biosynthetic process, enzymatic modification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in heparan sulfate proteoglycan biosynthetic process, enzymatic modification IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in heparan sulfate proteoglycan biosynthetic process, enzymatic modification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of multicellular organism growth IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Heparan-sulfate 6-O-sulfotransferase
    NP_001362017.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      5275561..5278519
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001375033.3 → NP_001362017.1  Heparan-sulfate 6-O-sulfotransferase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EFN7
      Conserved Domains (1) summary
      pfam03567
      Location:79 → 348
      Sulfotransfer_2; Sulfotransferase family
    Nucleotide Protein
    Heading Accession and Version

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