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    endu-2 Endoribonuclease [ Caenorhabditis elegans ]

    Gene ID: 181079, updated on 9-Dec-2024

    Summary

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    Official Symbol
    endu-2
    Official Full Name
    Endoribonuclease
    Primary source
    WormBase:WBGene00019779
    Locus tag
    CELE_M60.2
    See related
    AllianceGenome:WB:WBGene00019779
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable RNA endonuclease activity. Involved in defense response to Gram-negative bacterium and innate immune response. Is expressed in several structures, including germ line; head muscle; intestine; muscle cell; and neurons. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See endu-2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    9
    Sequence:
    Chromosome: X; NC_003284.9 (8242301..8247869)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene F-box domain-containing protein Neighboring gene ncRNA Neighboring gene MARVEL domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Ion transport domain-containing protein Neighboring gene Tetraspanin family protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Protection of germline immortality by the soma via a secreted endoribonuclease. Qi W, et al. Bioessays, 2021 Dec. PMID 34655094
    2. Author Correction: The secreted endoribonuclease ENDU-2 from the soma protects germline immortality in C. elegans. Qi W, et al. Nat Commun, 2021 May 28. PMID 34050169, Free PMC Article
    3. The secreted endoribonuclease ENDU-2 from the soma protects germline immortality in C. elegans. Qi W, et al. Nat Commun, 2021 Feb 24. PMID 33627668, Free PMC Article
    4. Endoribonuclease ENDU-2 regulates multiple traits including cold tolerance via cell autonomous and nonautonomous controls in Caenorhabditis elegans. Ujisawa T, et al. Proc Natl Acad Sci U S A, 2018 Aug 28. PMID 30104389, Free PMC Article
    5. Regulation of Nucleotide Metabolism and Germline Proliferation in Response to Nucleotide Imbalance and Genotoxic Stresses by EndoU Nuclease. Jia F, et al. Cell Rep, 2020 Feb 11. PMID 32049015, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ENDU-2 regulates cell type-dependent, cell-autonomous, and cell-nonautonomous cold tolerance.
      Title: Endoribonuclease ENDU-2 regulates multiple traits including cold tolerance via cell autonomous and nonautonomous controls in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA nuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to Gram-negative bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Endoribonuclease
    NP_509391.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      8242301..8247869
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_076990.8 → NP_509391.1  Endoribonuclease [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509391.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9GYM9
      Conserved Domains (1) summary
      pfam09412
      Location:307 → 571
      XendoU; Endoribonuclease XendoU
    Nucleotide Protein
    Heading Accession and Version

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