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    spe-45 Ig-like domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 185063, updated on 9-Dec-2024

    Summary

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    Official Symbol
    spe-45
    Official Full Name
    Ig-like domain-containing protein
    Primary source
    WormBase:WBGene00009217
    Locus tag
    CELE_F28D1.8
    See related
    AllianceGenome:WB:WBGene00009217
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be located in membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See spe-45 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    8
    Sequence:
    Chromosome: IV; NC_003282.8 (12387689..12390095, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Small ribosomal subunit protein uS12 Neighboring gene ncRNA Neighboring gene putative dolichol-phosphate mannosyltransferase subunit 3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. C. elegans spermatozoa lacking spe-45 are incapable of fusing with the oocyte plasma membrane. Takayama J, et al. MicroPubl Biol, 2021 Feb 21. PMID 33644705, Free PMC Article
    2. Marriage shrines and worms impacting our understanding of mammalian fertilization. Krauchunas AR, et al. Worm, 2016. PMID 27695649, Free PMC Article
    3. Forward Genetics Identifies a Requirement for the Izumo-like Immunoglobulin Superfamily spe-45 Gene in Caenorhabditis elegans Fertilization. Singaravelu G, et al. Curr Biol, 2015 Dec 21. PMID 26671668, Free PMC Article
    4. Gamete interactions require transmembranous immunoglobulin-like proteins with conserved roles during evolution. Nishimura H, et al. Worm, 2016. PMID 27695654, Free PMC Article
    5. The Immunoglobulin-like Gene spe-45 Acts during Fertilization in Caenorhabditis elegans like the Mouse Izumo1 Gene. Nishimura H, et al. Curr Biol, 2015 Dec 21. PMID 26671669, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. encodes a single-pass transmembrane protein with a single immunoglobulin domain; required for male fertility
      Title: Forward Genetics Identifies a Requirement for the Izumo-like Immunoglobulin Superfamily spe-45 Gene in Caenorhabditis elegans Fertilization.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ig-like domain-containing protein
    NP_001309449.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      12387689..12390095 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001322777.2 → NP_001309449.1  Ig-like domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q19879
      Conserved Domains (1) summary
      cd00096
      Location:176 → 230
      Ig; Immunoglobulin domain
    Nucleotide Protein
    Heading Accession and Version

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