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    • Showing Current items.

    C01A2.4 Charged multivesicular body protein 2b [ Caenorhabditis elegans ]

    Gene ID: 182050, updated on 9-Dec-2024

    Summary

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    Official Symbol
    C01A2.4
    Official Full Name
    Charged multivesicular body protein 2b
    Primary source
    WormBase:WBGene00007216
    Locus tag
    CELE_C01A2.4
    See related
    AllianceGenome:WB:WBGene00007216
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in endosome transport via multivesicular body sorting pathway; late endosome to vacuole transport; and protein transport. Predicted to be located in late endosome membrane. Predicted to be part of ESCRT III complex. Predicted to be active in multivesicular body. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; frontotemporal dementia; and frontotemporal dementia and/or amyotrophic lateral sclerosis 7. Orthologous to human CHMP2B (charged multivesicular body protein 2B). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See C01A2.4 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    5
    Sequence:
    Chromosome: I; NC_003279.8 (13392118..13394001)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Replication termination factor 2 Neighboring gene Membrane insertase YidC/Oxa/ALB C-terminal domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene MIP-1-5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A genome-wide study of PDZ-domain interactions in C. elegans reveals a high frequency of non-canonical binding. Lenfant N, et al. BMC Genomics, 2010 Nov 26. PMID 21110867, Free PMC Article
    2. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article
    3. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
    4. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in endosome transport via multivesicular body sorting pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in late endosome to vacuole transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vacuolar transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of ESCRT III complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in late endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in multivesicular body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Charged multivesicular body protein 2b
    NP_001369988.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      13392118..13394001
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001383742.2 → NP_001369988.1  Charged multivesicular body protein 2b [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      O02208
      Conserved Domains (1) summary
      pfam03357
      Location:16 → 185
      Snf7
    Nucleotide Protein
    Heading Accession and Version

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