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    eol-1 Decapping nuclease [ Caenorhabditis elegans ]

    Gene ID: 6418775, updated on 9-Dec-2024

    Summary

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    Official Symbol
    eol-1
    Official Full Name
    Decapping nuclease
    Primary source
    WormBase:WBGene00045401
    Locus tag
    CELE_T26F2.3
    See related
    AllianceGenome:WB:WBGene00045401
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable 5'-3' exonuclease activity; mRNA 5'-diphosphatase activity; and mRNA binding activity. Involved in regulation of olfactory learning. Predicted to be active in cytosol and nucleus. Is expressed in AVF; oxygen sensory neurons; and reproductive system. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See eol-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    5
    Sequence:
    Chromosome: V; NC_003283.11 (13979462..13980737, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Glycoside hydrolase family 19 catalytic domain-containing protein Neighboring gene pseudo Neighboring gene GATA-type domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. EOL-1, the homolog of the mammalian Dom3Z, regulates olfactory learning in C. elegans. Shen Y, et al. J Neurosci, 2014 Oct 1. PMID 25274815, Free PMC Article
    2. The Caenorhabditis elegans ARIP-4 DNA helicase couples mitochondrial surveillance to immune, detoxification, and antiviral pathways. Mao K, et al. Proc Natl Acad Sci U S A, 2022 Dec 6. PMID 36445965, Free PMC Article
    3. Mitochondrial dysfunction induces RNA interference in C. elegans through a pathway homologous to the mammalian RIG-I antiviral response. Mao K, et al. PLoS Biol, 2020 Dec. PMID 33264285, Free PMC Article
    4. The purine nucleoside phosphorylase pnp-1 regulates epithelial cell resistance to infection in C. elegans. Tecle E, et al. PLoS Pathog, 2021 Apr. PMID 33878133, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 5'-3' exonuclease activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA 5'-diphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA 5'-diphosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in NAD-cap decapping IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear mRNA surveillance ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in nuclear-transcribed mRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of olfactory learning IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Decapping nuclease
    NP_001123023.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      13979462..13980737 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001129551.5 → NP_001123023.1  Decapping nuclease [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001123023.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A5JYX9
    Nucleotide Protein
    Heading Accession and Version

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