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    pigs-1 GPI transamidase component PIG-S [ Caenorhabditis elegans ]

    Gene ID: 3565629, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pigs-1
    Official Full Name
    GPI transamidase component PIG-S
    Primary source
    WormBase:WBGene00011776
    Locus tag
    CELE_T14G10.7
    See related
    AllianceGenome:WB:WBGene00011776
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in attachment of GPI anchor to protein. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of GPI-anchor transamidase complex. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 95. Orthologous to human PIGS (phosphatidylinositol glycan anchor biosynthesis class S). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pigs-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    4
    Sequence:
    Chromosome: IV; NC_003282.8 (10147097..10149038, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene NAD(P)-binding protein Neighboring gene SH2 domain-containing protein Neighboring gene Tetraspanin-12 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Increasing Complexity of the N-Glycome During Caenorhabditis Development. Wilson IBH, et al. Mol Cell Proteomics, 2023 Mar. PMID 36717059, Free PMC Article
    2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in attachment of GPI anchor to protein IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in attachment of GPI anchor to protein IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of GPI-anchor transamidase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of GPI-anchor transamidase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    GPI transamidase component PIG-S
    NP_001369906.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      10147097..10149038 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001383182.2 → NP_001369906.1  GPI transamidase component PIG-S [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q22496
      Conserved Domains (1) summary
      pfam10510
      Location:57 → 542
      PIG-S; Phosphatidylinositol-glycan biosynthesis class S protein
    Nucleotide Protein
    Heading Accession and Version

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