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    • Showing Current items.

    ZK430.5 separase [ Caenorhabditis elegans ]

    Gene ID: 191319, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ZK430.5
    Official Full Name
    separase
    Primary source
    WormBase:WBGene00022741
    Locus tag
    CELE_ZK430.5
    See related
    AllianceGenome:WB:WBGene00022741
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable cysteine-type endopeptidase activity. Predicted to be involved in meiotic chromosome separation. Predicted to be active in cytoplasm; microtubule cytoskeleton; and nucleus. Orthologous to human ESPL1 (extra spindle pole bodies like 1, separase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ZK430.5 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    14
    Sequence:
    Chromosome: II; NC_003280.10 (4405658..4416553)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Forkhead transcription factor fkh-6 Neighboring gene Peroxidase mlt-7 light chain Neighboring gene Superoxide dismutase [Cu-Zn] Neighboring gene 3'(2'),5'-bisphosphate nucleotidase 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic chromosome separation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nuclear division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitotic spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    separase
    NP_001364682.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      4405658..4416553
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001377783.2 → NP_001364682.1  separase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q23491
      Conserved Domains (1) summary
      cl19248
      Location:737 → 1087
      CHAT; CHAT domain
    Nucleotide Protein
    Heading Accession and Version

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