cgt-2 Ceramide glucosyltransferase 2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: cgt-2
Official Full Name: Ceramide glucosyltransferase 2
Primary source: WormBase:WBGene00017625
Locus tag: CELE_F20B4.6
See related: AllianceGenome:WB:WBGene00017625
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ceramide glucosyltransferase activity. Predicted to be involved in glucosylceramide biosynthetic process. Predicted to be active in membrane. Is expressed in intestine and vulva. Orthologous to human UGCG (UDP-glucose ceramide glucosyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See cgt-2 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 7

Sequence:: Chromosome: X; NC_003284.9 (17695232..17701739)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Animals lacking CGT do not synthesize glycosphingolipids, arrest growth at the first larval stage, and display defects in a subset of cells in their digestive tract.
Title: Expression of ceramide glucosyltransferases, which are essential for glycosphingolipid synthesis, is only required in a small subset of C. elegans cells.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F20B4.6 (e-PCR)
- UniSTS:309847

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ceramide glucosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ceramide glucosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in glucosylceramide biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in sphingolipid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Ceramide glucosyltransferase 2

NP_510857.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

17695232..17701739

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_078456.6 → NP_510857.2 Ceramide glucosyltransferase 2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_510857.2

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EC84

Conserved Domains (2) summary

TIGR03472
Location:86 → 437

HpnI; hopanoid biosynthesis associated glycosyl transferase protein HpnI

cd02520
Location:98 → 329

Glucosylceramide_synthase; Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis