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    sms-5 Sphingomyelin synthase-related 2 [ Caenorhabditis elegans ]

    Gene ID: 189276, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sms-5
    Official Full Name
    Sphingomyelin synthase-related 2
    Primary source
    WormBase:WBGene00021075
    Locus tag
    CELE_W07E6.3
    See related
    AllianceGenome:WB:WBGene00021075
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ceramide cholinephosphotransferase activity and sphingomyelin synthase activity. Predicted to be involved in ceramide biosynthetic process and sphingomyelin biosynthetic process. Predicted to be located in membrane. Predicted to be active in Golgi membrane; endoplasmic reticulum membrane; and plasma membrane. Is expressed in pharynx and spermatheca. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See sms-5 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    7
    Sequence:
    Chromosome: II; NC_003280.10 (495424..498757)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene NLE domain-containing protein;WD_REPEATS_REGION domain-containing protein Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene Serpentine Receptor, class H

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The marginal cells of the Caenorhabditis elegans pharynx scavenge cholesterol and other hydrophobic small molecules. Kamal M, et al. Nat Commun, 2019 Sep 2. PMID 31477732, Free PMC Article
    2. PGP-14 establishes a polar lipid permeability barrier within the C. elegans pharyngeal cuticle. Kamal M, et al. PLoS Genet, 2023 Nov. PMID 37930961, Free PMC Article
    3. Phosphatidylcholine mediates the crosstalk between LET-607 and DAF-16 stress response pathways. He B, et al. PLoS Genet, 2021 May. PMID 34014977, Free PMC Article
    4. The FDA-approved drugs ticlopidine, sertaconazole, and dexlansoprazole can cause morphological changes in C. elegans. Galford KF, et al. Chemosphere, 2020 Dec. PMID 32731027, Free PMC Article
    5. Sphingolipid profiling reveals differential functions of sphingolipid biosynthesis isozymes of Caenorhabditis elegans. Luo H, et al. J Lipid Res, 2024 Jun. PMID 38704027, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ceramide cholinephosphotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables phosphotransferase activity, for other substituted phosphate groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sphingomyelin synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ceramide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sphingolipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sphingomyelin biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sphingomyelin biosynthetic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Sphingomyelin synthase-related 2
    NP_001293556.1
    • Confirmed by transcript evidence
    NP_001293557.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      495424..498757
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001306627.2 → NP_001293556.1  Sphingomyelin synthase-related 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293556.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9TYV2, U4PB50, U4PED8
      Conserved Domains (1) summary
      pfam14360
      Location:192 → 265
      PAP2_C; PAP2 superfamily C-terminal

    2. NM_001306628.3 → NP_001293557.1  Sphingomyelin synthase-related 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293557.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PB50
      Conserved Domains (1) summary
      pfam14360
      Location:86 → 159
      PAP2_C; PAP2 superfamily C-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9TYV2.2

    Gene LinkOut

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