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    ubc-22 UBiquitin Conjugating enzyme [ Caenorhabditis elegans ]

    Gene ID: 182322, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ubc-22
    Official Full Name
    UBiquitin Conjugating enzyme
    Primary source
    WormBase:WBGene00006717
    Locus tag
    CELE_C06E2.7
    See related
    AllianceGenome:WB:WBGene00006717
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in protein polyubiquitination. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ubc-22 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    6
    Sequence:
    Chromosome: X; NC_003284.9 (8867603..8869162, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Neuropeptide-Like Protein Neighboring gene INSulin related Neighboring gene Ubiquitin-conjugating enzyme E2 21 Neighboring gene ncRNA Neighboring gene GYF domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ubiquitination is involved in secondary growth, not initial formation of polyglutamine protein aggregates in C. elegans. Skibinski GA, et al. BMC Cell Biol, 2012 Apr 11. PMID 22494772, Free PMC Article
    2. Stress induced nuclear granules form in response to accumulation of misfolded proteins in Caenorhabditis elegans. Sampuda KM, et al. BMC Cell Biol, 2017 Apr 19. PMID 28424053, Free PMC Article
    3. Caenorhabditis elegans UBC-2 functions with the anaphase-promoting complex but also has other activities. Frazier T, et al. J Cell Sci, 2004 Oct 15. PMID 15466891
    4. The ubiquitin-conjugating enzyme UBE2K determines neurogenic potential through histone H3 in human embryonic stem cells. Fatima A, et al. Commun Biol, 2020 May 25. PMID 32451438, Free PMC Article
    5. Ubiquitin conjugating enzymes participate in polyglutamine protein aggregation. Howard RA, et al. BMC Cell Biol, 2007 Jul 30. PMID 17663792, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    UBiquitin Conjugating enzyme
    NP_509501.2
    • Product from WormBase gene class ubc;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      8867603..8869162 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_077100.6 → NP_509501.2  UBiquitin Conjugating enzyme [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509501.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q17720
      Conserved Domains (2) summary
      cl00154
      Location:5 → 128
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
      cl21463
      Location:139 → 174
      UBA_like_SF; UBA domain-like superfamily
    Nucleotide Protein
    Heading Accession and Version

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