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    sgcb-1 Beta-sarcoglycan [ Caenorhabditis elegans ]

    Gene ID: 186816, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sgcb-1
    Official Full Name
    Beta-sarcoglycan
    Primary source
    WormBase:WBGene00019277
    Locus tag
    CELE_K01A2.1
    See related
    AllianceGenome:WB:WBGene00019277
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in muscle organ development. Predicted to be located in membrane. Predicted to be part of sarcoglycan complex. Predicted to be active in sarcolemma. Is expressed in body wall musculature; enteric muscle; neurons; seam cell; and vulval muscle. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2E and muscular dystrophy. Orthologous to human SGCB (sarcoglycan beta). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See sgcb-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    6
    Sequence:
    Chromosome: II; NC_003280.10 (326300..328224)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Fatty Acid/Retinol binding protein Neighboring gene CCDC92 domain-containing protein;CCDC92/74 N-terminal domain-containing protein Neighboring gene EF-hand domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic evidence for a dystrophin-glycoprotein complex (DGC) in Caenorhabditis elegans. Grisoni K, et al. Gene, 2002 Jul 10. PMID 12234669
    2. Identification of novel target genes of CeTwist and CeE/DA. Wang P, et al. Dev Biol, 2006 May 15. PMID 16480708
    3. F-actin asymmetry and the endoplasmic reticulum-associated TCC-1 protein contribute to stereotypic spindle movements in the Caenorhabditis elegans embryo. Berends CW, et al. Mol Biol Cell, 2013 Jul. PMID 23699393, Free PMC Article
    4. The embryonic muscle transcriptome of Caenorhabditis elegans. Fox RM, et al. Genome Biol, 2007. PMID 17848203, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in muscle organ development IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of sarcoglycan complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of sarcoglycan complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in sarcolemma IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sarcolemma IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Beta-sarcoglycan
    NP_493710.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      326300..328224
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_061309.6 → NP_493710.2  Beta-sarcoglycan [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493710.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9TZ49
      Conserved Domains (1) summary
      pfam04790
      Location:27 → 277
      Sarcoglycan_1; Sarcoglycan complex subunit protein
    Nucleotide Protein
    Heading Accession and Version

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