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    fis-2 FIS1-related protein fis-2 [ Caenorhabditis elegans ]

    Gene ID: 184409, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fis-2
    Official Full Name
    FIS1-related protein fis-2
    Primary source
    WormBase:WBGene00001425
    Locus tag
    CELE_F13B9.8
    See related
    AllianceGenome:WB:WBGene00001425
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable lipid binding activity and molecular adaptor activity. Involved in apoptotic process. Acts upstream of or within IRE1-mediated unfolded protein response. Located in mitochondrion. Orthologous to human FIS1 (fission, mitochondrial 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See fis-2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    4
    Sequence:
    Chromosome: X; NC_003284.9 (8283275..8285219, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ZP domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Kinase suppressor of Ras A Neighboring gene ncRNA Neighboring gene Ground-like domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Effects of mutations in mitochondrial dynamics-related genes on the mitochondrial response to ultraviolet C radiation in developing Caenorhabditis elegans. Bess AS, et al. Worm, 2013 Jan 1. PMID 24058863, Free PMC Article
    2. One-step homozygosity in precise gene editing by an improved CRISPR/Cas9 system. Zhao P, et al. Cell Res, 2016 May. PMID 27055372, Free PMC Article
    3. Caenorhabditis elegans drp-1 and fis-2 regulate distinct cell-death execution pathways downstream of ced-3 and independent of ced-9. Breckenridge DG, et al. Mol Cell, 2008 Aug 22. PMID 18722182, Free PMC Article
    4. Mutations in Fis1 disrupt orderly disposal of defective mitochondria. Shen Q, et al. Mol Biol Cell, 2014 Jan. PMID 24196833, Free PMC Article
    5. Alcohol induces mitochondrial fragmentation and stress responses to maintain normal muscle function in Caenorhabditis elegans. Oh KH, et al. FASEB J, 2020 Jun. PMID 32294300, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables lipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within IRE1-mediated unfolded protein response HEP PubMed 
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mitochondrial fission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial fission IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peroxisome fission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in peroxisomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    FIS1-related protein fis-2
    NP_001024560.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      8283275..8285219 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001029389.7 → NP_001024560.1  FIS1-related protein fis-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024560.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q6AHP8
      Conserved Domains (1) summary
      cd12212
      Location:11 → 126
      Fis1; Mitochondrial Fission Protein Fis1, cytosolic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AHP8.1

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