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    farl-11 DUF3402 domain-containing protein;Far11/STRP C-terminal domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 174165, updated on 9-Dec-2024

    Summary

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    Official Symbol
    farl-11
    Official Full Name
    DUF3402 domain-containing protein;Far11/STRP C-terminal domain-containing protein
    Primary source
    WormBase:WBGene00017349
    Locus tag
    CELE_F10E7.8
    See related
    AllianceGenome:WB:WBGene00017349
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in endoplasmic reticulum organization; epithelial tube morphogenesis; and positive regulation of endocytic recycling. Located in endoplasmic reticulum. Is expressed in germ line. Orthologous to human STRIP1 (striatin interacting protein 1) and STRIP2 (striatin interacting protein 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See farl-11 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    9
    Sequence:
    Chromosome: II; NC_003280.10 (7101218..7105035, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene EF-hand domain-containing protein Neighboring gene Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene Methylmalonic aciduria type A homolog, mitochondrial Neighboring gene Large ribosomal subunit protein eL33 Neighboring gene Amino acid permease/ SLC12A domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. FARL-11 (STRIP1/2) is required for sarcomere and sarcoplasmic reticulum organization in C. elegans. Martin SCT, et al. Mol Biol Cell, 2023 Aug 1. PMID 37314837, Free PMC Article
    2. A role for post-transcriptional control of endoplasmic reticulum dynamics and function in C. elegans germline stem cell maintenance. Maheshwari R, et al. Development, 2016 Sep 1. PMID 27510976, Free PMC Article
    3. CCM-3/STRIPAK promotes seamless tube extension through endocytic recycling. Lant B, et al. Nat Commun, 2015 Mar 6. PMID 25743393
    4. STRIPAK regulation of katanin microtubule severing in the Caenorhabditis elegans embryo. Lu T, et al. Genetics, 2022 May 5. PMID 35298637, Free PMC Article
    5. CCM-3 Promotes C. elegans Germline Development by Regulating Vesicle Trafficking Cytokinesis and Polarity. Pal S, et al. Curr Biol, 2017 Mar 20. PMID 28285997

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FARL-11 (STRIP1/2) is required for sarcomere and sarcoplasmic reticulum organization in C. elegans.
      Title: FARL-11 (STRIP1/2) is required for sarcomere and sarcoplasmic reticulum organization in C. elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in epithelial tube morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of endocytic recycling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DUF3402 domain-containing protein;Far11/STRP C-terminal domain-containing protein
    NP_001333549.1
    • Confirmed by transcript evidence
    NP_001333550.1
    • Confirmed by transcript evidence
    NP_495467.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      7101218..7105035 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001346630.2 → NP_001333549.1  DUF3402 domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1D3PCL0
      Conserved Domains (2) summary
      pfam07923
      Location:77 → 405
      N1221; N1221-like protein
      pfam11882
      Location:553 → 924
      DUF3402; Domain of unknown function (DUF3402)

    2. NM_063066.9 → NP_495467.2  DUF3402 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495467.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q19300
      Conserved Domains (2) summary
      pfam07923
      Location:75 → 403
      N1221; N1221-like protein
      pfam11882
      Location:551 → 922
      DUF3402; Domain of unknown function (DUF3402)

    3. NM_001346631.3 → NP_001333550.1  Far11/STRP C-terminal domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1D3PD01
      Conserved Domains (1) summary
      pfam11882
      Location:2 → 122
      DUF3402; Domain of unknown function (DUF3402)
    Nucleotide Protein
    Heading Accession and Version

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