F35H10.6 Spindle and kinetochore-associated protein 2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: F35H10.6
Official Full Name: Spindle and kinetochore-associated protein 2
Primary source: WormBase:WBGene00018071
Locus tag: CELE_F35H10.6
See related: AllianceGenome:WB:WBGene00018071
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable unfolded protein binding activity. Predicted to be involved in RNA polymerase I assembly; RNA polymerase II core complex assembly; and RNA polymerase III assembly. Predicted to be part of prefoldin complex. Predicted to be active in cytoplasm. Orthologous to human UXT (ubiquitously expressed prefoldin like chaperone). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See F35H10.6 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 4

Sequence:: Chromosome: IV; NC_003282.8 (8299936..8300647)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F35H10.7 (e-PCR)
- UniSTS:310143

F35H10.6 (e-PCR)
- UniSTS:320721

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables unfolded protein binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in RNA polymerase I assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in RNA polymerase II core complex assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in RNA polymerase III assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein folding	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of prefoldin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of prefoldin complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Spindle and kinetochore-associated protein 2

NP_501397.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

8299936..8300647

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_068996.7 → NP_501397.2 Spindle and kinetochore-associated protein 2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_501397.2

Status: REVIEWED

UniProtKB/TrEMBL

Q20070

Conserved Domains (1) summary

cd00584
Location:15 → 141

Prefoldin_alpha; Prefoldin alpha subunit; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta ...