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    cblc-1 MMACHC-like protein [ Caenorhabditis elegans ]

    Gene ID: 3565644, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cblc-1
    Official Full Name
    MMACHC-like protein
    Primary source
    WormBase:WBGene00022766
    Locus tag
    CELE_ZK546.17
    See related
    AllianceGenome:WB:WBGene00022766
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables cobalamin binding activity. Predicted to be involved in cobalamin metabolic process; demethylation; and glutathione metabolic process. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in methylmalonic aciduria and homocystinuria type cblC. Orthologous to human MMACHC (metabolism of cobalamin associated C). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cblc-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    4
    Sequence:
    Chromosome: II; NC_003280.10 (4938596..4941150, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Glutathione S-Transferase Neighboring gene C2H2-type domain-containing protein Neighboring gene Energy transducer TonB Neighboring gene pseudo Neighboring gene Secreted protein Neighboring gene ncRNA Neighboring gene Mediator of RNA polymerase II transcription subunit 4 Neighboring gene Ribosomal RNA-processing protein 14/surfeit locus protein 6 C-terminal domain-containing protein;SURF6 homolog gldi-11

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Unusual aerobic stabilization of Cob(I)alamin by a B12-trafficking protein allows chemoenzymatic synthesis of organocobalamins. Li Z, et al. J Am Chem Soc, 2014 Nov 19. PMID 25369151, Free PMC Article
    2. Characterization of a B₁₂trafficking chaperone protein from caenorhabditis elegans. Park J, et al. Protein Pept Lett, 2015. PMID 25256267
    3. Glutathione-dependent one-electron transfer reactions catalyzed by a B₁₂ trafficking protein. Li Z, et al. J Biol Chem, 2014 Jun 6. PMID 24742678, Free PMC Article
    4. Coordination chemistry controls the thiol oxidase activity of the B(12)-trafficking protein CblC. Li Z, et al. J Biol Chem, 2017 Jun 9. PMID 28442570, Free PMC Article
    5. A dodecylamine derivative of cyanocobalamin potently inhibits the activities of cobalamin-dependent methylmalonyl-CoA mutase and methionine synthase of Caenorhabditis elegans. Bito T, et al. FEBS Open Bio, 2014. PMID 25161880, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The crystal structure of ceCblC provides insights into how architectural differences at the alpha- and beta-faces of cobalamin promote the thiol oxidase activity of ceCblC but mute it in wild-type human CblC.
      Title: Coordination chemistry controls the thiol oxidase activity of the B(12)-trafficking protein CblC.
    2. ability of the worm CblC to stabilize the highly reactive cob(I)alamin product of the glutathione transferase reaction
      Title: Unusual aerobic stabilization of Cob(I)alamin by a B12-trafficking protein allows chemoenzymatic synthesis of organocobalamins.
    3. These results demonstrate that cCblC is a Btrafficking chaperone of C. elegans catalyzing dealkylation and deglutathionylation via a nucleophilic displacement using the thiolate of GSH.
      Title: Characterization of a B₁₂trafficking chaperone protein from caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables FAD binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables FAD binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables cobalamin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cyanocobalamin reductase (cyanide-eliminating) (NADP+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cyanocobalamin reductase (cyanide-eliminating) (NADP+) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables demethylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables demethylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables glutathione binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cobalamin metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cobalamin metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in demethylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glutathione metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    MMACHC-like protein
    NP_001022524.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      4938596..4941150 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001027353.8 → NP_001022524.1  MMACHC-like protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022524.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7Z144
      Conserved Domains (1) summary
      pfam16690
      Location:24 → 260
      MMACHC; Methylmalonic aciduria and homocystinuria type C family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7Z144.1

    Gene LinkOut

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