stt-3 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit stt-3 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: stt-3
Official Full Name: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit stt-3
Primary source: WormBase:WBGene00020437
Locus tag: CELE_T12A2.2
See related: AllianceGenome:WB:WBGene00020437
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable dolichyl-diphosphooligosaccharide-protein glycotransferase activity. Predicted to be involved in post-translational protein modification and protein N-linked glycosylation via asparagine. Predicted to be located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ix. Orthologous to human STT3B (STT3 oligosaccharyltransferase complex catalytic subunit B). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See stt-3 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 5

Sequence:: Chromosome: III; NC_003281.10 (6248642..6251607)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T12A2.2 (e-PCR)
- UniSTS:310813

T12A2.8 (e-PCR)
- UniSTS:310817

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables dolichyl-diphosphooligosaccharide-protein glycotransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables dolichyl-diphosphooligosaccharide-protein glycotransferase activity	IEA Inferred from Electronic Annotation more info
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oligosaccharyl transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in post-translational protein modification	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein N-linked glycosylation via asparagine	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein glycosylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit stt-3

NP_498362.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

6248642..6251607

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_065961.6 → NP_498362.1 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit stt-3 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_498362.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P46975

Conserved Domains (2) summary

COG1287
Location:22 → 751

Stt3; Asparagine N-glycosylation enzyme, membrane subunit Stt3 [Posttranslational modification, protein turnover, chaperones]

pfam02516
Location:19 → 506

STT3; Oligosaccharyl transferase STT3 subunit