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    dgk-5 Diacylglycerol kinase;Putative diacylglycerol kinase K06A1.6 [ Caenorhabditis elegans ]

    Gene ID: 174068, updated on 27-Dec-2024

    Summary

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    Official Symbol
    dgk-5
    Official Full Name
    Diacylglycerol kinase;Putative diacylglycerol kinase K06A1.6
    Primary source
    WormBase:WBGene00019428
    Locus tag
    CELE_K06A1.6
    See related
    AllianceGenome:WB:WBGene00019428
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATP-dependent diacylglycerol kinase activity. Predicted to be involved in diacylglycerol metabolic process; intracellular signal transduction; and phosphatidic acid biosynthetic process. Predicted to be active in plasma membrane. Orthologous to human DGKI (diacylglycerol kinase iota) and DGKZ (diacylglycerol kinase zeta). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dgk-5 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    21
    Sequence:
    Chromosome: II; NC_003280.10 (6456512..6471085, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Nuclear hormone receptor family member nhr-22 Neighboring gene Autophagic-related protein 16.2 Neighboring gene Transcription factor aptf-1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Degenerin-like protein del-10 Neighboring gene Uncharacterized protein Neighboring gene Transmembrane protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Diacylglycerol lipase regulates lifespan and oxidative stress response by inversely modulating TOR signaling in Drosophila and C. elegans. Lin YH, et al. Aging Cell, 2014 Aug. PMID 24889782, Free PMC Article
    2. Adult-restricted gene knock-down reveals candidates that affect locomotive healthspan in C. elegans. Jushaj A, et al. Biogerontology, 2023 Apr. PMID 36662373
    3. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent diacylglycerol kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP-dependent diacylglycerol kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in diacylglycerol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidic acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Diacylglycerol kinase;Putative diacylglycerol kinase K06A1.6
    NP_001355399.1
    • Confirmed by transcript evidence
    NP_001355400.1
    • Confirmed by transcript evidence
    NP_001355416.1
    • Confirmed by transcript evidence
    NP_001355417.1
    • Confirmed by transcript evidence
    NP_495301.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      6456512..6471085 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001368593.5 → NP_001355400.1  Diacylglycerol kinase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A3B1DQ66
      Conserved Domains (3) summary
      smart00045
      Location:621 → 774
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:469 → 593
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cl00040
      Location:351 → 410
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

    2. NM_001368594.2 → NP_001355399.1  Diacylglycerol kinase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A3B1E8R6
      Conserved Domains (3) summary
      smart00045
      Location:576 → 729
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:424 → 548
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cl00040
      Location:306 → 365
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

    3. NM_062900.4 → NP_495301.1  Putative diacylglycerol kinase K06A1.6 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495301.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09588, Q10024
      Conserved Domains (3) summary
      smart00045
      Location:572 → 725
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:420 → 544
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      pfam00130
      Location:302 → 363
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    4. NM_001368596.3 → NP_001355417.1  Diacylglycerol kinase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A3B1E3M2
      Conserved Domains (4) summary
      smart00045
      Location:785 → 938
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:633 → 757
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      pfam17061
      Location:215 → 381
      PARM
      pfam00130
      Location:515 → 574
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    5. NM_001368595.4 → NP_001355416.1  Diacylglycerol kinase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A3B1DVJ7
      Conserved Domains (3) summary
      smart00045
      Location:510 → 663
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:358 → 482
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cl00040
      Location:240 → 299
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q10024.2

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