ric-19 Resistance to inhibitors of cholinesterase protein 19 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ric-19
Official Full Name: Resistance to inhibitors of cholinesterase protein 19
Primary source: WormBase:WBGene00004368
Locus tag: CELE_C32E8.7
See related: AllianceGenome:WB:WBGene00004368
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables small GTPase binding activity. Involved in dense core granule maturation; regulation of locomotion involved in locomotory behavior; and regulation of neurotransmitter secretion. Located in Golgi apparatus. Is expressed in several structures, including excretory system; head; intestine; muscle cell; and nervous system. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to several human genes including ICA1L (islet cell autoantigen 1 like). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ric-19 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 8

Sequence:: Chromosome: I; NC_003279.8 (3778089..3781690, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

UNC-108/RAB-2 and its effector RIC-19 are involved in dense core vesicle maturation in Caenorhabditis elegans.
Title: UNC-108/RAB-2 and its effector RIC-19 are involved in dense core vesicle maturation in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C32E8.7 (e-PCR)
- UniSTS:319097

C32E8.5 (e-PCR)
- UniSTS:308686

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IEA Inferred from Electronic Annotation more info
enables small GTPase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in dense core granule maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neurotransmitter transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of locomotion involved in locomotory behavior	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of neurotransmitter secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in endomembrane system	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Resistance to inhibitors of cholinesterase protein 19

NP_491216.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

3778089..3781690 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_058815.5 → NP_491216.2 Resistance to inhibitors of cholinesterase protein 19 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_491216.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P91124

Conserved Domains (1) summary

cl12013
Location:58 → 262

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature