jac-1 Fibronectin type-III domain-containing protein;Juxtamembrane domain-associated catenin [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: jac-1
Official Full Name: Fibronectin type-III domain-containing protein;Juxtamembrane domain-associated catenin
Primary source: WormBase:WBGene00002175
Locus tag: CELE_Y105C5B.21
See related: AllianceGenome:WB:WBGene00002175
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables cadherin binding activity. Involved in embryonic body morphogenesis; regulation of actin cytoskeleton organization; and regulation of protein localization. Located in adherens junction. Part of catenin complex. Is expressed in head. Human ortholog(s) of this gene implicated in DiGeorge syndrome; anxiety disorder; blepharocheilodontic syndrome 2; major depressive disorder; and schizophrenia. Orthologous to several human genes including ARVCF (ARVCF delta catenin family member). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See jac-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 15

Sequence:: Chromosome: IV; NC_003282.8 (15997835..16026847, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables cadherin binding	IBA Inferred from Biological aspect of Ancestor more info
enables cadherin binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in embryonic body morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of actin cytoskeleton organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of protein localization	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
located_in adherens junction	IDA Inferred from Direct Assay more info	PubMed
located_in adherens junction	IEA Inferred from Electronic Annotation more info
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
part_of catenin complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Fibronectin type-III domain-containing protein;Juxtamembrane domain-associated catenin

NP_001041007.1

Confirmed by transcript evidence

NP_001041008.1

Confirmed by transcript evidence

NP_001255881.1

Confirmed by transcript evidence

NP_001255882.1

Confirmed by transcript evidence

NP_001294123.1

Confirmed by transcript evidence

NP_001294124.1

Confirmed by transcript evidence

NP_001294125.1

Confirmed by transcript evidence

NP_001294126.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

15997835..16026847 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001307197.4 → NP_001294126.1 Fibronectin type-III domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001294126.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A078BQQ1

Conserved Domains (3) summary

cd00020
Location:445 → 564

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

cd00063
Location:70 → 160

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

sd00043
Location:450 → 475

ARM; armadillo repeat [structural motif]
NM_001047542.3 → NP_001041007.1 Juxtamembrane domain-associated catenin [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001041007.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q2HQL5, Q9U308

Conserved Domains (3) summary

cd00020
Location:688 → 807

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

cd00063
Location:313 → 403

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

sd00043
Location:693 → 718

ARM; armadillo repeat [structural motif]
NM_001307194.3 → NP_001294123.1 Fibronectin type-III domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001294123.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A078BS85

Conserved Domains (3) summary

cd00020
Location:688 → 807

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

cd00063
Location:313 → 403

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

sd00043
Location:693 → 718

ARM; armadillo repeat [structural motif]
NM_001268953.4 → NP_001255882.1 Fibronectin type-III domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255882.1

Status: REVIEWED

UniProtKB/TrEMBL

D3DEL8

Conserved Domains (3) summary

cd00020
Location:445 → 564

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

cd00063
Location:70 → 160

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

sd00043
Location:450 → 475

ARM; armadillo repeat [structural motif]
NM_001268952.3 → NP_001255881.1 Fibronectin type-III domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255881.1

Status: REVIEWED

UniProtKB/TrEMBL

D3DEL7

Conserved Domains (3) summary

cd00020
Location:615 → 734

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

cd00063
Location:240 → 330

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

sd00043
Location:620 → 645

ARM; armadillo repeat [structural motif]
NM_001307195.3 → NP_001294124.1 Fibronectin type-III domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001294124.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A078BPN7

Conserved Domains (3) summary

cd00020
Location:615 → 734

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

cd00063
Location:240 → 330

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

sd00043
Location:620 → 645

ARM; armadillo repeat [structural motif]
NM_001047543.4 → NP_001041008.1 Juxtamembrane domain-associated catenin [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001041008.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9U308

Conserved Domains (3) summary

cd00020
Location:518 → 637

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

cd00063
Location:143 → 233

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

sd00043
Location:523 → 548

ARM; armadillo repeat [structural motif]
NM_001307196.3 → NP_001294125.1 Fibronectin type-III domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001294125.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A078BPM1

Conserved Domains (3) summary

cd00020
Location:518 → 637

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

cd00063
Location:143 → 233

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

sd00043
Location:523 → 548

ARM; armadillo repeat [structural motif]