rcan-1 Calcipressin-like protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: rcan-1
Official Full Name: Calcipressin-like protein
Primary source: WormBase:WBGene00004321
Locus tag: CELE_F54E7.7
See related: AllianceGenome:WB:WBGene00004321
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables protein phosphatase 2B binding activity and protein serine/threonine phosphatase inhibitor activity. Involved in several processes, including male mating behavior; positive regulation of nematode male tail tip morphogenesis; and thermosensory behavior. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including non-striated muscle; pharyngeal cell; somatic nervous system; tail; and vulva. Used to study Down syndrome. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human RCAN3 (RCAN family member 3); RCAN1 (regulator of calcineurin 1); and RCAN2 (regulator of calcineurin 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See rcan-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 4

Sequence:: Chromosome: III; NC_003281.10 (5682301..5684098, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study identified a spontaneous genetic change that increases exploration behavior and fitness of C. elegans in laboratory environments. Interestingly, this genetic change is not a simple genetic change that deletes or changes the sequence of a protein product, but rather a complex structural variant that simultaneously duplicates the rcan-1 gene and modifies its expression in several tissues.
Title: A spontaneous complex structural variant in rcan-1 increases exploratory behavior and laboratory fitness of Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F54E7.7 (e-PCR)
- UniSTS:314458

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables calcium-dependent protein serine/threonine phosphatase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase 2B binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine phosphatase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in calcium-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium-mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in calcium-mediated signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of nematode male tail tip morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to hermaphrodite contact	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in thermosensory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vulval location	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: Calcipressin-like protein

NP_498223.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

5682301..5684098 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_065822.7 → NP_498223.2 Calcipressin-like protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_498223.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P53806, Q9U6V5

Conserved Domains (1) summary

cl17169
Location:41 → 201

RRM_SF; RNA recognition motif (RRM) superfamily