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    xpg-1 XPG (Xeroderma Pigmentosum group G) DNA repair gene homolog [ Caenorhabditis elegans ]

    Gene ID: 186441, updated on 9-Dec-2024

    Summary

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    Official Symbol
    xpg-1
    Official Full Name
    XPG (Xeroderma Pigmentosum group G) DNA repair gene homolog
    Primary source
    WormBase:WBGene00019004
    Locus tag
    CELE_F57B10.6
    See related
    AllianceGenome:WB:WBGene00019004
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable 5'-flap endonuclease activity. Predicted to be involved in double-strand break repair via homologous recombination. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in several diseases, including cerebrooculofacioskeletal syndrome 3; melanoma; respiratory system cancer (multiple); stomach cancer; and xeroderma pigmentosum group G. Orthologous to human ERCC5 (ERCC excision repair 5, endonuclease). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See xpg-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    9
    Sequence:
    Chromosome: I; NC_003279.8 (6558694..6562346)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Trehalase Neighboring gene ncRNA Neighboring gene GOLD domain-containing protein Neighboring gene BAG family molecular chaperone regulator 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DNA damage leads to progressive replicative decline but extends the life span of long-lived mutant animals. Lans H, et al. Cell Death Differ, 2013 Dec. PMID 24013725, Free PMC Article
    2. Nucleotide Excision Repair in Caenorhabditis elegans. Lans H, et al. Mol Biol Int, 2011. PMID 22091407, Free PMC Article
    3. The Caenorhabditis elegans homolog of Gen1/Yen1 resolvases links DNA damage signaling to DNA double-strand break repair. Bailly AP, et al. PLoS Genet, 2010 Jul 15. PMID 20661466, Free PMC Article
    4. Involvement of global genome repair, transcription coupled repair, and chromatin remodeling in UV DNA damage response changes during development. Lans H, et al. PLoS Genet, 2010 May 6. PMID 20463888, Free PMC Article
    5. Systematic analysis of DNA crosslink repair pathways during development and aging in Caenorhabditis elegans. Wilson DM 3rd, et al. Nucleic Acids Res, 2017 Sep 19. PMID 28934497, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    XPG (Xeroderma Pigmentosum group G) DNA repair gene homolog
    NP_491891.2
    • Product from WormBase gene class xpg;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      6558694..6562346
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059490.4 → NP_491891.2  XPG (Xeroderma Pigmentosum group G) DNA repair gene homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491891.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O44737
      Conserved Domains (2) summary
      cd09900
      Location:554 → 586
      H3TH_XPG-like; H3TH domains of Flap endonuclease-1 (FEN1)-like structure specific 5' nucleases: FEN1 (archaeal), GEN1, YEN1, and XPG
      cl14812
      Location:1 → 111
      PIN_SF; PIN (PilT N terminus) domain: Superfamily
    Nucleotide Protein
    Heading Accession and Version

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