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    his-24 Histone 24 [ Caenorhabditis elegans ]

    Gene ID: 181545, updated on 9-Dec-2024

    Summary

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    Official Symbol
    his-24
    Official Full Name
    Histone 24
    Primary source
    WormBase:WBGene00001898
    Locus tag
    CELE_M163.3
    See related
    AllianceGenome:WB:WBGene00001898
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables H3K27me3 modified histone binding activity. Involved in chromatin remodeling; defense response to Gram-positive bacterium; and negative regulation of gene expression. Located in chromosome, telomeric region; cytoplasm; and nucleus. Is expressed in several structures, including germ line; gonad; head; intestine; and pharynx. Orthologous to human H1-0 (H1.0 linker histone) and H1-8 (H1.8 linker histone). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See his-24 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    2
    Sequence:
    Chromosome: X; NC_003284.9 (14490094..14491119)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ShKT domain-containing protein Neighboring gene ncRNA Neighboring gene tRNA-Lys Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene C2H2-type domain-containing protein Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Linker histones: novel insights into structure-specific recognition of the nucleosome. Cutter AR, et al. Biochem Cell Biol, 2017 Apr. PMID 28177778, Free PMC Article
    2. Identification of a Caenorhabditis elegans histone H1 gene family. Characterization of a family member containing an intron and encoding a poly(A)+ mRNA. Sanicola M, et al. J Mol Biol, 1990 Mar 20. PMID 1969492
    3. HIS-24 linker histone and SIR-2.1 deacetylase induce H3K27me3 in the Caenorhabditis elegans germ line. Wirth M, et al. Mol Cell Biol, 2009 Jul. PMID 19380489, Free PMC Article
    4. Interplay between histone deacetylase SIR-2, linker histone H1 and histone methyltransferases in heterochromatin formation. Wirth M, et al. Epigenetics, 2009 Aug 16. PMID 19736527
    5. Imaging embryonic development in Caenorhabditis elegans. Mohler WA, et al. Cold Spring Harb Protoc, 2010 Mar. PMID 20194475

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Caenorhabditis elegans H1 variant his-24, hpl-1, and hpl-2 coregulate the expression of genes linked to immune response.
      Title: Novel roles of Caenorhabditis elegans heterochromatin protein HP1 and linker histone in the regulation of innate immune gene expression.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables H3K27me3 modified histone binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleosomal DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural constituent of chromatin IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromosome condensation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in defense response to Gram-positive bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of DNA recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleosome assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, telomeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nucleosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Histone 24
    NP_510410.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      14490094..14491119
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078009.7 → NP_510410.1  Histone 24 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_510410.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P10771, Q93901
      Conserved Domains (1) summary
      pfam00538
      Location:38 → 112
      Linker_histone; linker histone H1 and H5 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P10771.4

    Gene LinkOut

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