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    spe-8 Spermatocyte protein spe-8 [ Caenorhabditis elegans ]

    Gene ID: 171606, updated on 9-Dec-2024

    Summary

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    Official Symbol
    spe-8
    Official Full Name
    Spermatocyte protein spe-8
    Primary source
    WormBase:WBGene00004962
    Locus tag
    CELE_F53G12.6
    See related
    AllianceGenome:WB:WBGene00004962
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable non-membrane spanning protein tyrosine kinase activity and signaling receptor binding activity. Involved in spermatid development. Located in plasma membrane. Is expressed in sperm and spermatocyte. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See spe-8 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    7
    Sequence:
    Chromosome: I; NC_003279.8 (118093..120901)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Collagen triple helix repeat protein;Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene Growth-regulating factor;K Homology domain-containing protein Neighboring gene LisH domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mitopherogenesis, a form of mitochondria-specific ectocytosis, regulates sperm mitochondrial quantity and fertility. Liu P, et al. Nat Cell Biol, 2023 Nov. PMID 37945830
    2. Evolution of larger sperm in response to experimentally increased sperm competition in Caenorhabditis elegans. LaMunyon CW, et al. Proc Biol Sci, 2002 Jun 7. PMID 12061955, Free PMC Article
    3. The micronutrient element zinc modulates sperm activation through the SPE-8 pathway in Caenorhabditis elegans. Liu Z, et al. Development, 2013 May. PMID 23578924
    4. Calcium signaling and the MAPK cascade are required for sperm activation in Caenorhabditis elegans. Liu Z, et al. Biochim Biophys Acta, 2014 Feb. PMID 24239721
    5. Proteinase K is an activator for the male-dependent spermiogenesis pathway in Caenorhabditis elegans: Its application to pharmacological dissection of spermiogenesis. Tajima T, et al. Genes Cells, 2019 Mar. PMID 30656805

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatid development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Spermatocyte protein spe-8
    NP_490680.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      118093..120901
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058279.2 → NP_490680.1  Spermatocyte protein spe-8 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_490680.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O01798
      Conserved Domains (3) summary
      smart00219
      Location:217 → 475
      TyrKc; Tyrosine kinase, catalytic domain
      cd10361
      Location:109 → 195
      SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
      cd00192
      Location:221 → 476
      PTKc; Catalytic domain of Protein Tyrosine Kinases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O01798.2

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