sbt-1 Neuroendocrine protein 7B2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: sbt-1
Official Full Name: Neuroendocrine protein 7B2
Primary source: WormBase:WBGene00011392
Locus tag: CELE_T03D8.3
See related: AllianceGenome:WB:WBGene00011392
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables peptidase activator activity and peptidase inhibitor activity. Involved in regulation of muscle contraction. Predicted to be located in extracellular region and secretory granule. Is expressed in neurons and pharynx. Orthologous to human SCG5 (secretogranin V). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See sbt-1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 3

Sequence:: Chromosome: V; NC_003283.11 (20827715..20828881, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The regulation of aging by unc-13 and sbt-1 is temperature-dependent. And the alterations in reproduction capability and stress response may be associated with the formation of this temperature-dependent property
Title: Regulation of aging by unc-13 and sbt-1 in Caenorhabditis elegans is temperature-dependent.
Identification of 7B2 (Seven B Two) in C. elegans by homology searching; partial overlap of function with mammalian 7B2.
Title: Cloning and functional analysis of C. elegans 7B2.
The presence and/or absence of some neuropeptides in 7B2-null animals strongly differs form the peptide profile in wild-type, suggesting a specific and determined action of 7B2 in C. elegans.
Title: Altered neuropeptide profile of Caenorhabditis elegans lacking the chaperone protein 7B2 as analyzed by mass spectrometry.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T03D8.3 (e-PCR)
- UniSTS:316108

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables enzyme regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptidase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables peptidase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in regulation of hormone secretion	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of muscle contraction	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in secretory granule	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Neuroendocrine protein 7B2

NP_508020.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

20827715..20828881 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_075619.9 → NP_508020.1 Neuroendocrine protein 7B2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_508020.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9XTY3

Conserved Domains (1) summary

pfam05281
Location:41 → 205

Secretogranin_V; Neuroendocrine protein 7B2 precursor (Secretogranin V)