wdr-48 WD repeat-containing protein 48 homolog [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: wdr-48
Official Full Name: WD repeat-containing protein 48 homolog
Primary source: WormBase:WBGene00009441
Locus tag: CELE_F35G12.4
See related: AllianceGenome:WB:WBGene00009441
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ubiquitin binding activity. Involved in positive regulation of locomotion involved in locomotory behavior; positive regulation of macromolecule metabolic process; and positive regulation of protein localization to cell surface. Is expressed in anal depressor muscle; head neurons; mu_int_L; mu_int_R; and tail. Orthologous to human WDR48 (WD repeat domain 48). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See wdr-48 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 14

Sequence:: Chromosome: III; NC_003281.10 (4578853..4581697)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The WD40-repeat protein WDR-48 promotes the stability of the deubiquitinating enzyme USP-46 by inhibiting its ubiquitination and degradation.
Title: The WD40-repeat protein WDR-48 promotes the stability of the deubiquitinating enzyme USP-46 by inhibiting its ubiquitination and degradation.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F35G12.3 (e-PCR)
- UniSTS:317484

F35G12.4 (e-PCR)
- UniSTS:307599

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in double-strand break repair via homologous recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of locomotion involved in locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein deubiquitination	IPI Inferred from Physical Interaction more info	PubMed
involved_in positive regulation of protein localization to cell surface	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: WD repeat-containing protein 48 homolog

NP_001129837.1

Confirmed by transcript evidence

NP_497930.2

Confirmed by transcript evidence

NP_497931.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

4578853..4581697

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_065530.8 → NP_497931.2 WD repeat-containing protein 48 homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_497931.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q20059

Conserved Domains (4) summary

COG2319
Location:2 → 376

WD40; WD40 repeat [General function prediction only]

cd00200
Location:29 → 322

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam11816
Location:530 → 678

DUF3337; Domain of unknown function (DUF3337)

sd00039
Location:32 → 88

7WD40; WD40 repeat [structural motif]
NM_065529.9 → NP_497930.2 WD repeat-containing protein 48 homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_497930.2

Status: REVIEWED

UniProtKB/Swiss-Prot

B3GWA7, Q20059, Q9U3G8

Conserved Domains (4) summary

COG2319
Location:2 → 376

WD40; WD40 repeat [General function prediction only]

cd00200
Location:29 → 322

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam11816
Location:530 → 681

DUF3337; Domain of unknown function (DUF3337)

sd00039
Location:32 → 88

7WD40; WD40 repeat [structural motif]
NM_001136365.4 → NP_001129837.1 WD repeat-containing protein 48 homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001129837.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q20059

Conserved Domains (4) summary

COG2319
Location:2 → 376

WD40; WD40 repeat [General function prediction only]

cd00200
Location:29 → 322

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam11816
Location:530 → 695

DUF3337; Domain of unknown function (DUF3337)

sd00039
Location:32 → 88

7WD40; WD40 repeat [structural motif]