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    hpo-19 NADH-cytochrome b5 reductase [ Caenorhabditis elegans ]

    Gene ID: 179029, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hpo-19
    Official Full Name
    NADH-cytochrome b5 reductase
    Primary source
    WormBase:WBGene00020268
    Locus tag
    CELE_T05H4.5
    See related
    AllianceGenome:WB:WBGene00020268
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable FAD binding activity. Predicted to be located in membrane. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in breast cancer and methemoglobinemia. Orthologous to human CYB5R1 (cytochrome b5 reductase 1); CYB5R2 (cytochrome b5 reductase 2); and CYB5R3 (cytochrome b5 reductase 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See hpo-19 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    5
    Sequence:
    Chromosome: V; NC_003283.11 (6436645..6437884)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Gastrulation defective protein 1 Neighboring gene Eukaryotic peptide chain release factor subunit 1 Neighboring gene NADH-cytochrome b5 reductase Neighboring gene F-box associated domain-containing protein;FBA_2 domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The cytochrome b5 reductase HPO-19 is required for biosynthesis of polyunsaturated fatty acids in Caenorhabditis elegans. Zhang Y, et al. Biochim Biophys Acta, 2016 Apr. PMID 26806391
    2. Cytochrome b5 reductase: the roles of the recessive congenital methemoglobinemia mutants P144L, L148P, and R159*. Davis CA, et al. Arch Biochem Biophys, 2004 Nov 15. PMID 15488472
    3. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article
    4. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cytochrome b5 reductase HPO-19/T05H4.4 is required for desaturation to biosynthesize PUFAs in C. elegans.
      Title: The cytochrome b5 reductase HPO-19 is required for biosynthesis of polyunsaturated fatty acids in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables FAD binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cytochrome-b5 reductase activity, acting on NAD(P)H IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    NADH-cytochrome b5 reductase
    NP_504638.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      6436645..6437884
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_072237.7 → NP_504638.1  NADH-cytochrome b5 reductase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_504638.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O16521
      Conserved Domains (2) summary
      cd06183
      Location:53 → 309
      cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
      PTZ00319
      Location:9 → 309
      PTZ00319; NADH-cytochrome B5 reductase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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