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    gcy-33 Soluble guanylate cyclase gcy-33;guanylate cyclase [ Caenorhabditis elegans ]

    Gene ID: 179644, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gcy-33
    Official Full Name
    Soluble guanylate cyclase gcy-33;guanylate cyclase
    Primary source
    WormBase:WBGene00001553
    Locus tag
    CELE_F57F5.2
    See related
    AllianceGenome:WB:WBGene00001553
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables carbon monoxide sensor activity; nitric oxide binding activity; and oxygen sensor activity. Involved in chemosensory behavior; response to oxygen levels; and sensory perception of bitter taste. Predicted to be located in cytoplasm. Predicted to be part of guanylate cyclase complex, soluble. Is expressed in oxygen sensory neurons. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gcy-33 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    11
    Sequence:
    Chromosome: V; NC_003283.11 (11995805..12001797, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Cyclin L homolog cyl-1 Neighboring gene Histidine kinase Neighboring gene Essential MCU regulator, mitochondrial Neighboring gene ncRNA Neighboring gene tRNA-Ile Neighboring gene ncRNA Neighboring gene Peptidase C1A papain C-terminal domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Probing domain interactions in soluble guanylate cyclase. Derbyshire ER, et al. Biochemistry, 2011 May 24. PMID 21491957, Free PMC Article
    2. A single amino acid change in the EGL-46 transcription factor causes defects in BAG neuron specification. Godini R, et al. MicroPubl Biol, 2020 Feb 25. PMID 32550488, Free PMC Article
    3. Guanylate cyclases link serotoninergic signaling to modulate ethanol-induced food intake in C. elegans. Wang X, et al. Biochem Biophys Res Commun, 2021 Aug 27. PMID 34133999
    4. New insights on the functions of the guanylyl cyclase receptors. Wedel BJ, et al. FEBS Lett, 1997 Jun 23. PMID 9247117
    5. Oxygen-sensing neurons reciprocally regulate peripheral lipid metabolism via neuropeptide signaling in Caenorhabditis elegans. Hussey R, et al. PLoS Genet, 2018 Mar. PMID 29579048, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carbon monoxide sensor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables guanylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanylate cyclase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nitric oxide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nitric oxide binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxygen sensor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxygen sensor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxygen sensor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cGMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chemosensory behavior IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in chemosensory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cyclic nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nitric oxide-cGMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to oxygen levels IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to oxygen levels IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sensory perception of bitter taste IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in sensory perception of bitter taste IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of guanylate cyclase complex, soluble IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Soluble guanylate cyclase gcy-33;guanylate cyclase
    NP_001256391.1
    • Confirmed by transcript evidence
    NP_001256392.1
    • Partially confirmed by transcript evidence
    NP_001256393.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      11995805..12001797 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001269462.4 → NP_001256391.1  Soluble guanylate cyclase gcy-33 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256391.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P90895, Q18791, Q86C59
      Conserved Domains (6) summary
      smart00044
      Location:400 → 596
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      COG5134
      Location:593 → 742
      COG5134; Uncharacterized conserved protein [Function unknown]
      pfam07700
      Location:2 → 164
      HNOB; Haem-NO-binding
      pfam07701
      Location:204 → 421
      HNOBA; Heme NO binding associated
      pfam17084
      Location:708 → 896
      TDA11; Topoisomerase I damage affected protein 11
      cl11967
      Location:431 → 616
      Nucleotidyl_cyc_III; Class III nucleotidyl cyclases

    2. NM_001269463.3 → NP_001256392.1  guanylate cyclase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256392.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2L2D1
      Conserved Domains (5) summary
      smart00044
      Location:402 → 598
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      COG5134
      Location:595 → 744
      COG5134; Uncharacterized conserved protein [Function unknown]
      pfam17084
      Location:710 → 898
      TDA11; Topoisomerase I damage affected protein 11
      pfam07701
      Location:204 → 423
      HNOBA; Heme NO binding associated
      pfam07700
      Location:2 → 164
      HNOB; Haem-NO-binding

    3. NM_001269464.3 → NP_001256393.1  Soluble guanylate cyclase gcy-33 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256393.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EGJ1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P90895.4

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