pyc-1 Pyruvate carboxylase 1;Pyruvate carboxylase subunit B [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: pyc-1
Official Full Name: Pyruvate carboxylase 1;Pyruvate carboxylase subunit B
Primary source: WormBase:WBGene00004258
Locus tag: CELE_D2023.2
See related: AllianceGenome:WB:WBGene00004258
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable pyruvate carboxylase activity. Predicted to be involved in gluconeogenesis and pyruvate metabolic process. Located in mitochondrion. Used to study pyruvate decarboxylase deficiency. Human ortholog(s) of this gene implicated in pyruvate carboxylase deficiency disease. Orthologous to human PC (pyruvate carboxylase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See pyc-1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 9

Sequence:: Chromosome: V; NC_003283.11 (11817783..11822365, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D2023.2 (e-PCR)
- UniSTS:321318

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables ligase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables pyruvate carboxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables pyruvate carboxylase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in gluconeogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in gluconeogenesis	IEA Inferred from Electronic Annotation more info
involved_in pyruvate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in pyruvate metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed

General protein information

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Preferred Names: Pyruvate carboxylase 1;Pyruvate carboxylase subunit B

NP_001368099.1

Confirmed by transcript evidence

NP_001369995.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

11817783..11822365 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001383412.2 → NP_001369995.1 Pyruvate carboxylase 1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

O17732

Conserved Domains (1) summary

PRK12999
Location:28 → 1175

PRK12999; pyruvate carboxylase; Reviewed
NM_001380776.1 → NP_001368099.1 Pyruvate carboxylase subunit B [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

H2L2E4

Conserved Domains (1) summary

cl39082
Location:2 → 616

PycA; Pyruvate carboxylase [Energy production and conversion]