T25B9.9 6-phosphogluconate dehydrogenase, decarboxylating [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: T25B9.9
Official Full Name: 6-phosphogluconate dehydrogenase, decarboxylating
Primary source: WormBase:WBGene00012015
Locus tag: CELE_T25B9.9
See related: AllianceGenome:WB:WBGene00012015
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable NADP binding activity and phosphogluconate dehydrogenase (decarboxylating) activity. Involved in defense response to Gram-negative bacterium and negative regulation of gene expression. Predicted to be active in cytosol. Orthologous to human PGD (phosphogluconate dehydrogenase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See T25B9.9 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 7

Sequence:: Chromosome: IV; NC_003282.8 (10769653..10777743)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T25B9.9 (e-PCR)
- UniSTS:318535

T25B9.10 (e-PCR)
- UniSTS:306352

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables NADP binding	IBA Inferred from Biological aspect of Ancestor more info
enables NADP binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables phosphogluconate dehydrogenase (decarboxylating) activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphogluconate dehydrogenase (decarboxylating) activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in D-gluconate catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in D-gluconate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in defense response to Gram-negative bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pentose-phosphate shunt	IEA Inferred from Electronic Annotation more info
involved_in pentose-phosphate shunt, oxidative branch	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: 6-phosphogluconate dehydrogenase, decarboxylating

NP_501998.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

10769653..10777743

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_069597.8 → NP_501998.1 6-phosphogluconate dehydrogenase, decarboxylating [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_501998.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q17761, Q22772

Conserved Domains (3) summary

PRK09287
Location:14 → 474

PRK09287; 6-phosphogluconate dehydrogenase; Validated

pfam00393
Location:179 → 470

6PGD; 6-phosphogluconate dehydrogenase, C-terminal domain

pfam03446
Location:4 → 174

NAD_binding_2; NAD binding domain of 6-phosphogluconate dehydrogenase