zyg-8 Serine/threonine-protein kinase zyg-8;non-specific serine/threonine protein kinase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: zyg-8
Official Full Name: Serine/threonine-protein kinase zyg-8;non-specific serine/threonine protein kinase
Primary source: WormBase:WBGene00006993
Locus tag: CELE_Y79H2A.11
See related: AllianceGenome:WB:WBGene00006993
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables microtubule binding activity. Involved in several processes, including establishment of mitotic spindle localization; thermosensory behavior; and thermotaxis. Located in cytoplasm and microtubule cytoskeleton. Is expressed in several structures, including amphid neurons; germ line; motor neurons; touch receptor neurons; and ventral nerve cord. Used to study dyslexia. Orthologous to human DCLK1 (doublecortin like kinase 1) and DCLK2 (doublecortin like kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See zyg-8 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 9

Sequence:: Chromosome: III; NC_003281.10 (12061713..12072070)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The doublecortin-family kinase ZYG-8DCLK1 regulates microtubule dynamics and motor-driven forces to promote the stability of C. elegans acentrosomal spindles.
Title: The doublecortin-family kinase ZYG-8DCLK1 regulates microtubule dynamics and motor-driven forces to promote the stability of C. elegans acentrosomal spindles.
The EFA-6 N-terminus binds the microtubule-associated proteins TAC-1/Transforming-Acidic-Coiled-Coil, and ZYG-8/Doublecortin-Like-Kinase, both of which are required for regenerative growth cone formation, and which act downstream of EFA-6.
Title: Axon injury triggers EFA-6 mediated destabilization of axonal microtubules via TACC and doublecortin like kinase.
Zyg-8 promotes structural integrity, length and number of individual microtubules.
Title: The doublecortin-related gene zyg-8 is a microtubule organizer in Caenorhabditis elegans neurons.
These findings indicate that ZYG-9-TAC-1 and ZYG-8 act in a partially redundant manner to ensure correct microtubule assembly throughout the cell cycle of early C. elegans embryos.
Title: ZYG-9, TAC-1 and ZYG-8 together ensure correct microtubule function throughout the cell cycle of C. elegans embryos.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y75B8A.36 (e-PCR)
- UniSTS:322443

Y79H2A.11 (e-PCR)
- UniSTS:321779

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell cycle	IEA Inferred from Electronic Annotation more info
involved_in establishment of mitotic spindle localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in mitotic DNA damage checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of microtubule depolymerization	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in thermosensory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in thermotaxis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in microtubule cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in mitotic spindle microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in mitotic spindle pole	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Serine/threonine-protein kinase zyg-8;non-specific serine/threonine protein kinase

NP_001334209.1

Confirmed by transcript evidence

NP_499571.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

12061713..12072070

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_067170.8 → NP_499571.2 Serine/threonine-protein kinase zyg-8 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_499571.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q95QC4, Q9U1S0

Conserved Domains (3) summary

smart00220
Location:482 → 743

S_TKc; Serine/Threonine protein kinases, catalytic domain

smart00537
Location:206 → 298

DCX; Domain in the Doublecortin (DCX) gene product

cd14095
Location:481 → 742

STKc_DCKL; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase (also called Doublecortin-like and CAM kinase-like)
NM_001347293.3 → NP_001334209.1 non-specific serine/threonine protein kinase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1I6CM54