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    hizr-1 High zinc activated nuclear receptor protein [ Caenorhabditis elegans ]

    Gene ID: 191322, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hizr-1
    Official Full Name
    High zinc activated nuclear receptor protein
    Primary source
    WormBase:WBGene00013976
    Locus tag
    CELE_ZK455.6
    See related
    AllianceGenome:WB:WBGene00013976
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables DNA-binding transcription factor activity; cis-regulatory region sequence-specific DNA binding activity; and zinc ion binding activity. Involved in intracellular zinc ion homeostasis and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in head and intestine. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See hizr-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    13
    Sequence:
    Chromosome: X; NC_003284.9 (11318278..11321078)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Laminin N-terminal domain-containing protein Neighboring gene Neuropeptide-Like Protein Neighboring gene Sphingomyelin phosphodiesterase 2 Neighboring gene Nucleotide-diphospho-sugar transferase domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cadmium hijacks the high zinc response by binding and activating the HIZR-1 nuclear receptor. Earley BJ, et al. Proc Natl Acad Sci U S A, 2021 Oct 19. PMID 34649987, Free PMC Article
    2. The Nuclear Receptor HIZR-1 Uses Zinc as a Ligand to Mediate Homeostasis in Response to High Zinc. Warnhoff K, et al. PLoS Biol, 2017 Jan. PMID 28095401, Free PMC Article
    3. Mediator subunit MDT-15/MED15 and Nuclear Receptor HIZR-1/HNF4 cooperate to regulate toxic metal stress responses in Caenorhabditis elegans. Shomer N, et al. PLoS Genet, 2019 Dec. PMID 31815936, Free PMC Article
    4. A pathway for low zinc homeostasis that is conserved in animals and acts in parallel to the pathway for high zinc homeostasis. Dietrich N, et al. Nucleic Acids Res, 2017 Nov 16. PMID 28977437, Free PMC Article
    5. BLIMP-1/BLMP-1 and Metastasis-Associated Protein Regulate Stress Resistant Development in Caenorhabditis elegans. Hyun M, et al. Genetics, 2016 Aug. PMID 27334271, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cadmium hijacks the high zinc response by binding and activating the HIZR-1 nuclear receptor.
      Title: Cadmium hijacks the high zinc response by binding and activating the HIZR-1 nuclear receptor.
    2. Data show that mdt-15 and hizr-1 cooperate to regulate cadmium detoxification and zinc storage and that this mechanism is at least partially conserved in mammals.
      Title: Mediator subunit MDT-15/MED15 and Nuclear Receptor HIZR-1/HNF4 cooperate to regulate toxic metal stress responses in Caenorhabditis elegans.
    3. The essential micronutrient zinc acts as a HIZR-1 ligand, and activated HIZR-1 increases transcription of genes that promote zinc efflux and storage.
      Title: The Nuclear Receptor HIZR-1 Uses Zinc as a Ligand to Mediate Homeostasis in Response to High Zinc.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables cis-regulatory region sequence-specific DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular zinc ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    High zinc activated nuclear receptor protein
    NP_509893.3
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      11318278..11321078
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_077492.7 → NP_509893.3  High zinc activated nuclear receptor protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509893.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5ED47
      Conserved Domains (2) summary
      smart00399
      Location:13 → 82
      ZnF_C4; c4 zinc finger in nuclear hormone receptors
      smart00430
      Location:195 → 365
      HOLI; Ligand binding domain of hormone receptors
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5ED47.1

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