twk-18 TWiK family of potassium channels protein 18 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: twk-18
Official Full Name: TWiK family of potassium channels protein 18
Primary source: WormBase:WBGene00006672
Locus tag: CELE_C24A3.6
See related: AllianceGenome:WB:WBGene00006672
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables outward rectifier potassium channel activity. Involved in locomotion; muscle contraction; and potassium ion transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in body wall musculature. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See twk-18 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 8

Sequence:: Chromosome: X; NC_003284.9 (8988137..8991975)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C24A3.6 (e-PCR)
- UniSTS:313725

C24A3.5 (e-PCR)
- UniSTS:315579

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables outward rectifier potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables outward rectifier potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables outward rectifier potassium channel activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables potassium channel activity	IEA Inferred from Electronic Annotation more info
enables potassium ion leak channel activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IC Inferred by Curator more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: TWiK family of potassium channels protein 18

NP_001379714.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

8988137..8991975

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001392816.1 → NP_001379714.1 TWiK family of potassium channels protein 18 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q18120, Q9TZP8

Conserved Domains (1) summary

pfam07885
Location:114 → 170

Ion_trans_2; Ion channel