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    snr-3 putative small nuclear ribonucleoprotein Sm D1;snRNP core protein D1 [ Caenorhabditis elegans ]

    Gene ID: 174072, updated on 9-Dec-2024

    Summary

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    Official Symbol
    snr-3
    Official Full Name
    putative small nuclear ribonucleoprotein Sm D1;snRNP core protein D1
    Primary source
    WormBase:WBGene00004916
    Locus tag
    CELE_T28D9.10
    See related
    AllianceGenome:WB:WBGene00004916
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in spliceosomal snRNP assembly. Located in P granule. Is expressed in gonad. Human ortholog(s) of this gene implicated in connective tissue disease; nephritis; proteinuria; and systemic lupus erythematosus. Orthologous to human SNRPD1 (small nuclear ribonucleoprotein D1 polypeptide). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See snr-3 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    4
    Sequence:
    Chromosome: II; NC_003280.10 (6488830..6489761, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene putative lin-8 family protein lido-16 Neighboring gene Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein;Phospholipid phosphatase homolog 1.2 homolog Neighboring gene putative splicing factor, arginine/serine-rich 5 Neighboring gene Uncharacterized protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel function for the Sm proteins in germ granule localization during C. elegans embryogenesis. Barbee SA, et al. Curr Biol, 2002 Sep 3. PMID 12225665
    2. PUF-8 and TCER-1 are essential for normal levels of multiple mRNAs in the C. elegans germline. Pushpa K, et al. Development, 2013 Mar. PMID 23444359, Free PMC Article
    3. RG/RGG repeats in the C. elegans homologs of Nucleolin and GAR1 contribute to sub-nucleolar phase separation. Spaulding EL, et al. Nat Commun, 2022 Nov 3. PMID 36329008, Free PMC Article
    4. RSR-2, the Caenorhabditis elegans ortholog of human spliceosomal component SRm300/SRRM2, regulates development by influencing the transcriptional machinery. Fontrodona L, et al. PLoS Genet, 2013 Jun. PMID 23754964, Free PMC Article
    5. The ribonucleotidyl transferase USIP-1 acts with SART3 to promote U6 snRNA recycling. Rüegger S, et al. Nucleic Acids Res, 2015 Mar 31. PMID 25753661, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spliceosomal snRNP assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in P granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SMN-Sm protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U1 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U2 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U4 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U5 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of commitment complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of pICln-Sm protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of precatalytic spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of spliceosomal tri-snRNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    putative small nuclear ribonucleoprotein Sm D1;snRNP core protein D1
    NP_001317766.1
    • Confirmed by transcript evidence
    NP_495306.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      6488830..6489761 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001330951.3 → NP_001317766.1  snRNP core protein D1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      M1ZJ32
      Conserved Domains (1) summary
      cl00259
      Location:1 → 59
      Sm_like; Sm and related proteins

    2. NM_062905.8 → NP_495306.1  putative small nuclear ribonucleoprotein Sm D1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495306.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q10013
      Conserved Domains (1) summary
      cd01724
      Location:2 → 88
      Sm_D1; Sm protein D1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q10013.1

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