coq-3 Ubiquinone biosynthesis O-methyltransferase, mitochondrial [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: coq-3
Official Full Name: Ubiquinone biosynthesis O-methyltransferase, mitochondrial
Primary source: WormBase:WBGene00000763
Locus tag: CELE_Y57G11C.11
See related: AllianceGenome:WB:WBGene00000763
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable 3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity. Involved in nematode larval development and ubiquinone biosynthetic process. Predicted to be located in mitochondrial inner membrane. Predicted to be extrinsic component of mitochondrial inner membrane. Predicted to be active in mitochondrion. Is expressed in intestine. Orthologous to human COQ3 (coenzyme Q3, methyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See coq-3 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 5

Sequence:: Chromosome: IV; NC_003282.8 (14793104..14796324, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

An extra-chromosomal array expressing wild-type coq-3 rescued fertility of both coq-3 mutants and partially restored steady-state levels of COQ-3 polypeptide and Q(9) content, indicating that primary defect in both is limited to coq-3.
Title: Restoring de novo coenzyme Q biosynthesis in Caenorhabditis elegans coq-3 mutants yields profound rescue compared to exogenous coenzyme Q supplementation.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y57G11C.12 (e-PCR)
- UniSTS:321094

Y57G11C.11 (e-PCR)
- UniSTS:322431

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables 3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables 3-demethylubiquinol-n 3-O-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in methylation	IEA Inferred from Electronic Annotation more info
involved_in nematode larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ubiquinone biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquinone biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in ubiquinone biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extrinsic component of mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in extrinsic component of mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Ubiquinone biosynthesis O-methyltransferase, mitochondrial

NP_001041045.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

14793104..14796324 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001047580.5 → NP_001041045.1 Ubiquinone biosynthesis O-methyltransferase, mitochondrial [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001041045.1

Status: REVIEWED

UniProtKB/TrEMBL

O18235

Conserved Domains (2) summary

TIGR01983
Location:32 → 262

UbiG; ubiquinone biosynthesis O-methyltransferase

pfam12847
Location:75 → 188

Methyltransf_18; Methyltransferase domain