U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    irk-3 IRK_C domain-containing protein;Inward rectifier potassium channel C-terminal domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 191696, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    irk-3
    Official Full Name
    IRK_C domain-containing protein;Inward rectifier potassium channel C-terminal domain-containing protein
    Primary source
    WormBase:WBGene00002151
    Locus tag
    CELE_K04G11.5
    See related
    AllianceGenome:WB:WBGene00002151
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable inward rectifier potassium channel activity. Involved in short-term memory. Predicted to be located in membrane. Predicted to be part of monoatomic ion channel complex. Predicted to be active in plasma membrane. Is expressed in neurons. Human ortholog(s) of this gene implicated in Bartter disease type 2; EAST syndrome; Leber congenital amaurosis 16; autosomal recessive nonsyndromic deafness 4; and snowflake vitreoretinal degeneration. Orthologous to several human genes including KCNJ10 (potassium inwardly rectifying channel subfamily J member 10); KCNJ13 (potassium inwardly rectifying channel subfamily J member 13); and KCNJ15 (potassium inwardly rectifying channel subfamily J member 15). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See irk-3 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    11
    Sequence:
    Chromosome: X; NC_003284.9 (14353290..14370370, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene RSD-2 N-terminal domain-containing protein Neighboring gene WD repeat-containing protein wdr-5.2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Reduced Ca(2+) transient amplitudes may signify increased or decreased depolarization depending on the neuromodulatory signaling pathway. Debnath A, et al. Front Neurosci, 2022. PMID 35937887, Free PMC Article
    2. The C. elegans adult neuronal IIS/FOXO transcriptome reveals adult phenotype regulators. Kaletsky R, et al. Nature, 2016 Jan 7. PMID 26675724, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables inward rectifier potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables inward rectifier potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of monoatomic ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in short-term memory IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of monoatomic ion channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    IRK_C domain-containing protein;Inward rectifier potassium channel C-terminal domain-containing protein
    NP_001317893.1
    • Confirmed by transcript evidence
    NP_001317903.1
    • Confirmed by transcript evidence
    NP_001317904.1
    • Confirmed by transcript evidence
    NP_001317905.1
    • Confirmed by transcript evidence
    NP_001368607.1
    • Confirmed by transcript evidence
    NP_001379171.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      14353290..14370370 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001330918.4 → NP_001317893.1  IRK_C domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1C3NSR4
      Conserved Domains (2) summary
      pfam17655
      Location:191 → 354
      IRK_C; Inward rectifier potassium channel C-terminal domain
      cl21560
      Location:50 → 184
      Ion_trans_2; Ion channel

    2. NM_001392886.1 → NP_001379171.1  IRK_C domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q93849
      Conserved Domains (2) summary
      pfam17655
      Location:186 → 349
      IRK_C; Inward rectifier potassium channel C-terminal domain
      cl21560
      Location:40 → 179
      Ion_trans_2; Ion channel

    3. NM_001330921.5 → NP_001317904.1  IRK_C domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1C3NSL2
      Conserved Domains (2) summary
      pfam17655
      Location:57 → 220
      IRK_C; Inward rectifier potassium channel C-terminal domain
      cl21560
      Location:1 → 50
      Ion_trans_2; Ion channel

    4. NM_001381146.1 → NP_001368607.1  IRK_C domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1C3NSK2
      Conserved Domains (2) summary
      pfam17655
      Location:196 → 359
      IRK_C; Inward rectifier potassium channel C-terminal domain
      cl21560
      Location:50 → 189
      Ion_trans_2; Ion channel

    5. NM_001330920.4 → NP_001317903.1  IRK_C domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1C3NSS7
      Conserved Domains (2) summary
      pfam17655
      Location:181 → 344
      IRK_C; Inward rectifier potassium channel C-terminal domain
      cl21560
      Location:40 → 174
      Ion_trans_2; Ion channel

    6. NM_001330922.4 → NP_001317905.1  Inward rectifier potassium channel C-terminal domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1C3NSP8
      Conserved Domains (1) summary
      pfam17655
      Location:1 → 103
      IRK_C; Inward rectifier potassium channel C-terminal domain
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools