hmp-2 Armadillo/beta-catenin-like repeat protein;Beta-catenin-like protein hmp-2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: hmp-2
Official Full Name: Armadillo/beta-catenin-like repeat protein;Beta-catenin-like protein hmp-2
Primary source: WormBase:WBGene00001979
Locus tag: CELE_K05C4.6
See related: AllianceGenome:WB:WBGene00001979
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables several functions, including alpha-catenin binding activity; cadherin binding activity; and transcription coactivator activity. Involved in several processes, including cytoskeleton organization; embryonic morphogenesis; and left/right axis specification. Located in adherens junction and nucleus. Part of catenin complex. Is expressed in distal tip cell; germ cell; and intestine. Human ortholog(s) of this gene implicated in several diseases, including cardiomyopathy (multiple); hepatocellular carcinoma (multiple); palmoplantar keratosis (multiple); reproductive organ cancer (multiple); and urinary system cancer (multiple). Orthologous to several human genes including JUP (junction plakoglobin). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See hmp-2 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 6

Sequence:: Chromosome: I; NC_003279.8 (14738882..14742671)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deletion analysis based on the crystal structure shows that the first helix of HMP-1 is necessary for binding HMP-2 avidly in vitro and for efficient recruitment of HMP-1 to adherens junctions in embryos. HMP-2 Ser-47 and Tyr-69 flank its binding interface with HMP-1, and we show that phosphomimetic mutations at these two sites decrease binding affinity of HMP-1 to HMP-2 by 40-100-fold
Title: Cell-cell adhesion in metazoans relies on evolutionarily conserved features of the α-catenin·β-catenin-binding interface.
HMP-1 bound filamentous actin with an affinity in the single micromolar range, even when complexed with the beta-catenin homolog HMP-2 or when present in a complex of HMP-2 and the cadherin homolog HMR-1, indicating that HMP-1 binding to F-actin is not allosterically regulated by the HMP-2.HMR-1 complex.
Title: Structural and functional characterization of Caenorhabditis elegans α-catenin reveals constitutive binding to β-catenin and F-actin.
The beta-catenin HMP-2 functions downstream of Src in parallel with the Wnt pathway in early embryogenesis of C. elegans.
Title: The β-catenin HMP-2 functions downstream of Src in parallel with the Wnt pathway in early embryogenesis of C. elegans.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

K05C4.6 (e-PCR)
- UniSTS:312944

K05C4.7 (e-PCR)
- UniSTS:312945

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables alpha-catenin binding	IBA Inferred from Biological aspect of Ancestor more info
enables alpha-catenin binding	IPI Inferred from Physical Interaction more info	PubMed
enables cadherin binding	IBA Inferred from Biological aspect of Ancestor more info
enables cadherin binding	IEA Inferred from Electronic Annotation more info
enables cadherin binding	IPI Inferred from Physical Interaction more info	PubMed
enables molecular function inhibitor activity	IPI Inferred from Physical Interaction more info	PubMed
enables nuclear receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase binding	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell migration involved in gastrulation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cortical actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic body morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of mitotic spindle orientation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in left/right axis specification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of cell division	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of protein localization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
located_in adherens junction	IDA Inferred from Direct Assay more info	PubMed
located_in adherens junction	IEA Inferred from Electronic Annotation more info
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
part_of catenin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of catenin complex	IDA Inferred from Direct Assay more info	PubMed
part_of catenin complex	IPI Inferred from Physical Interaction more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Armadillo/beta-catenin-like repeat protein;Beta-catenin-like protein hmp-2

NP_001252425.1

Partially confirmed by transcript evidence

NP_001252426.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

14738882..14742671

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001265496.4 → NP_001252425.1 Armadillo/beta-catenin-like repeat protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001252425.1

Status: REVIEWED

UniProtKB/TrEMBL

H2L2I2

Conserved Domains (5) summary

cd00020
Location:357 → 473

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

pfam00514
Location:305 → 346

Arm; Armadillo/beta-catenin-like repeat

pfam13646
Location:106 → 185

HEAT_2; HEAT repeats

sd00044
Location:106 → 137

HEAT; HEAT repeat [structural motif]

sd00043
Location:358 → 383

ARM; armadillo repeat [structural motif]
NM_001265497.4 → NP_001252426.1 Beta-catenin-like protein hmp-2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001252426.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O44326

Conserved Domains (5) summary

cd00020
Location:331 → 447

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

pfam00514
Location:279 → 320

Arm; Armadillo/beta-catenin-like repeat

pfam13646
Location:80 → 159

HEAT_2; HEAT repeats

sd00044
Location:80 → 111

HEAT; HEAT repeat [structural motif]

sd00043
Location:332 → 357

ARM; armadillo repeat [structural motif]