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    akt-2 Serine/threonine-protein kinase akt-2 [ Caenorhabditis elegans ]

    Gene ID: 181524, updated on 27-Dec-2024

    Summary

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    Official Symbol
    akt-2
    Official Full Name
    Serine/threonine-protein kinase akt-2
    Primary source
    WormBase:WBGene00000103
    Locus tag
    CELE_F28H6.1
    See related
    AllianceGenome:WB:WBGene00000103
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables phosphatidylinositol-3,4,5-trisphosphate binding activity and protein serine/threonine kinase activity. Involved in determination of adult lifespan; insulin receptor signaling pathway; and regulation of synaptic assembly at neuromuscular junction. Is expressed in several structures, including excretory canal; neurons; pharynx; rectum; and vulva. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); gastrointestinal system cancer (multiple); glucose metabolism disease (multiple); pancreatic cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human AKT1 (AKT serine/threonine kinase 1); AKT2 (AKT serine/threonine kinase 2); and AKT3 (AKT serine/threonine kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See akt-2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    8
    Sequence:
    Chromosome: X; NC_003284.9 (14147700..14152070)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene kynurenine--oxoglutarate transaminase Neighboring gene Homeodomain-only protein Neighboring gene Homeobox domain-containing protein Neighboring gene Neurotransmitter-gated ion-channel ligand-binding domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Morusin and mulberrin extend the lifespans of yeast and C. elegans via suppressing nutrient-sensing pathways. Xu P, et al. Geroscience, 2023 Apr. PMID 36462128, Free PMC Article
    2. Lactobacillus fermentum WC2020 increased the longevity of Caenorhabditis elegans via JNK-mediated antioxidant pathway. Yang X, et al. J Food Sci, 2024 Jun. PMID 38638065
    3. [Effect of Ligusticum chuanxiong extract on lifespan of Caenorhabditis elegans and its underlying molecular mechanisms]. Wang X, et al. Zhongguo Zhong Yao Za Zhi, 2010 Apr. PMID 20617690
    4. Reduced expression of BTBD10, an Akt activator, leads to motor neuron death. Nawa M, et al. Cell Death Differ, 2012 Aug. PMID 22388351, Free PMC Article
    5. Reconstruction of the insulin-like signalling pathway of Haemonchus contortus. Mohandas N, et al. Parasit Vectors, 2016 Feb 3. PMID 26842675, Free PMC Article

    See all (94) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3,4,5-trisphosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in insulin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of synaptic assembly at neuromuscular junction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Serine/threonine-protein kinase akt-2
    NP_001024612.1
    • Confirmed by transcript evidence
    NP_510357.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      14147700..14152070
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001029441.4 → NP_001024612.1  Serine/threonine-protein kinase akt-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024612.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9XTG7
      Conserved Domains (4) summary
      smart00220
      Location:180 → 437
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd01241
      Location:11 → 116
      PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
      pfam00169
      Location:13 → 115
      PH; PH domain
      cl21453
      Location:184 → 468
      PKc_like; Protein Kinases, catalytic domain

    2. NM_077956.8 → NP_510357.3  Serine/threonine-protein kinase akt-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_510357.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O77145, Q9XTG7
      Conserved Domains (4) summary
      smart00220
      Location:180 → 437
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd01241
      Location:11 → 116
      PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
      pfam00169
      Location:13 → 115
      PH; PH domain
      cl21453
      Location:184 → 509
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XTG7.1

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