Htr5a 5-hydroxytryptamine receptor 5A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Htr5aprovided by RGD
Official Full Name: 5-hydroxytryptamine receptor 5Aprovided by RGD
Primary source: RGD:2851
See related: AllianceGenome:RGD:2851
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: MR22; 5HT5A
Summary: Enables G protein-coupled serotonin receptor activity. Involved in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; hippocampus development; and response to estradiol. Located in dendrite and perikaryon. Is active in postsynaptic specialization membrane. Orthologous to human HTR5A (5-hydroxytryptamine receptor 5A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 30.0) See more
Orthologs: human mouse all
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Genomic context

Location:: 4q11

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (8178802..8188485, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (7444968..7454651, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (199916..209599)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The 5-HT2A, 5-HT5A, and 5-HT6 serotonergic receptors in the medial prefrontal cortex behave differently in extinction learning: Does social support play a role?
Title: The 5-HT2A, 5-HT5A, and 5-HT6 serotonergic receptors in the medial prefrontal cortex behave differently in extinction learning: Does social support play a role?
Role of peripheral 5-HT5A receptors in 5-HT-induced cardiac sympatho-inhibition in type 1 diabetic rats.
Title: Role of peripheral 5-HT(5A) receptors in 5-HT-induced cardiac sympatho-inhibition in type 1 diabetic rats.
results suggest that 5-HT5A receptors reduce pain processing in the spinal cord
Title: Role of spinal 5-HT5A, and 5-HT1A/1B/1D, receptors in neuropathic pain induced by spinal nerve ligation in rats.
Even though 5-HT5A receptor gene expression does not change in the hippocampus of any treated group, in rats that are treated with leptin and serotonin, immunostaining specific for 5-HT5A serotonin receptor decreases significantly in the dentate gyrus.
Title: Serotonin receptor 5-HT5A in rat hippocampus decrease by leptin treatment.
The gene coding for the 5-HT 5A receptor is already active in the embryonic rat brain and is differentially expressed during development.
Title: Developmental expression of 5-HT 5A receptor mRNA in the rat brain.
5-HT5A receptor-like immunoreactivity has been observed in neuronal somata of the cerebellar cortex and deep cerebellar nuclei.
Title: Localization of 5-HT2A, 5-HT3, 5-HT5A and 5-HT7 receptor-like immunoreactivity in the rat cerebellum.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled serotonin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled serotonin receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables G protein-coupled serotonin receptor activity	ISO Inferred from Sequence Orthology more info
enables Gi/o-coupled serotonin receptor activity	ISO Inferred from Sequence Orthology more info
enables Gi/o-coupled serotonin receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables neurotransmitter receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables serotonin receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-inhibiting serotonin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-inhibiting serotonin receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in hippocampus development	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in postsynaptic specialization membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: 5-hydroxytryptamine receptor 5A

Names: 5-HT-5A; 5-HT5A; 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled; REC17; serotonin receptor 5A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013148.2 → NP_037280.1 5-hydroxytryptamine receptor 5A

See identical proteins and their annotated locations for NP_037280.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000004

UniProtKB/Swiss-Prot

P35364

UniProtKB/TrEMBL

A6KJK9

Conserved Domains (2) summary

cd14964
Location:42 → 68

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:41 → 349

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily