Exog exo/endonuclease G [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Exogprovided by RGD
Official Full Name: exo/endonuclease Gprovided by RGD
Primary source: RGD:1304628
See related: EnsemblRapid:ENSRNOG00000014801 AllianceGenome:RGD:1304628
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Endogl1
Summary: Predicted to enable 5'-3' exonuclease activity; RNA endonuclease activity; and single-stranded DNA endodeoxyribonuclease activity. Predicted to be involved in apoptotic DNA fragmentation. Predicted to be located in mitochondrion. Predicted to be part of protein-containing complex. Predicted to be active in mitochondrial inner membrane and nucleus. Orthologous to human EXOG (exo/endonuclease G). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 27.7), Brain (RPKM 24.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q32

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (128062688..128082529)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (119184974..119204819)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (128133398..128153110)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PGC-1a Mediated-EXOG, a Specific Repair Enzyme for Mitochondrial DNA, Plays an Essential Role in the Rotenone-Induced Neurotoxicity of PC12 Cells.
Title: PGC-1ɑ Mediated-EXOG, a Specific Repair Enzyme for Mitochondrial DNA, Plays an Essential Role in the Rotenone-Induced Neurotoxicity of PC12 Cells.
Endo/exonuclease G-like plays an essential role in cardiomyocyte physiology. Loss of endo/exonuclease G-like results in diminished adaptation to pathological stress. The decline in maximal respiration and reserve capacity is the first sign of mitochondrial dysfunction that determines subsequent cell death.
Title: In EXOG-depleted cardiomyocytes cell death is marked by a decreased mitochondrial reserve capacity of the electron transport chain.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 5'-3' exonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables 5'-3' exonuclease activity	ISO Inferred from Sequence Orthology more info
enables RNA endonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables endonuclease activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables single-stranded DNA endodeoxyribonuclease activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in apoptotic DNA fragmentation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: nuclease EXOG, mitochondrial

Names: endo/exonuclease (5'-3'), endonuclease G-like; endonuclease G-like 1

NP_001100336.1

EC 3.1.30.-

XP_006244150.2

EC 3.1.30.-

XP_038937228.1

EC 3.1.30.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106866.3 → NP_001100336.1 nuclease EXOG, mitochondrial precursor

See identical proteins and their annotated locations for NP_001100336.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A6I3W8, A6I3W9, D3ZTW9

Related

ENSRNOP00000020174.4, ENSRNOT00000020174.7

Conserved Domains (1) summary

smart00477
Location:77 → 286

NUC; DNA/RNA non-specific endonuclease

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

128062688..128082529

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006244088.4 → XP_006244150.2 nuclease EXOG, mitochondrial isoform X1

UniProtKB/TrEMBL

A6I3W8

Related

ENSRNOP00000111424.1, ENSRNOT00000131964.1

Conserved Domains (2) summary

smart00477
Location:152 → 361

NUC; DNA/RNA non-specific endonuclease

pfam18026
Location:377 → 425

Exog_C; Endo/exonuclease (EXOG) C-terminal domain
XM_039081300.2 → XP_038937228.1 nuclease EXOG, mitochondrial isoform X2

UniProtKB/TrEMBL

A6I3X2, A6I3X3

Conserved Domains (2) summary

pfam18026
Location:149 → 197

Exog_C; Endo/exonuclease (EXOG) C-terminal domain

cl00089
Location:1 → 133

NUC; DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers.