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    Lilrb4 leukocyte immunoglobulin like receptor B4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 292594, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lilrb4provided by RGD
    Official Full Name
    leukocyte immunoglobulin like receptor B4provided by RGD
    Primary source
    RGD:1359090
    See related
    EnsemblRapid:ENSRNOG00000027811 AllianceGenome:RGD:1359090
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gp49b; GP49B2
    Summary
    Predicted to enable several functions, including apolipoprotein binding activity; fibronectin binding activity; and transmembrane receptor protein tyrosine kinase inhibitor activity. Predicted to be involved in several processes, including negative regulation of cytokine production; regulation of leukocyte activation; and regulation of signal transduction. Predicted to be located in cell surface. Predicted to be active in plasma membrane. Orthologous to human LILRB4 (leukocyte immunoglobulin like receptor B4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 129.2), Kidney (RPKM 103.1) and 8 other tissues See more
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    Genomic context

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    See Lilrb4 in Genome Data Viewer
    Location:
    1q12
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (78847685..78853294, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (69805020..69810628, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (73393854..73399448, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1 Neighboring gene motile sperm domain containing 1, pseudogene 1 Neighboring gene leukocyte immunoglobulin like receptor B4, pseudogene 1 Neighboring gene leukocyte immunoglobulin like receptor B3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Lilrb4 ameliorates ileal injury in rats with hemorrhagic shock and suppresses the activation of NF-κB signaling pathway. Jin H, et al. Biochim Biophys Acta Mol Basis Dis, 2024 Apr. PMID 38367899
    2. The rat orthologue to the inhibitory receptor gp49B is expressed by neutrophils and monocytes, but not by NK cells or mast cells. Bryceson YT, et al. Eur J Immunol, 2005 Apr. PMID 15756648
    3. Inhibitory immunoglobulin-like receptors LILRB and PIR-B negatively regulate osteoclast development. Mori Y, et al. J Immunol, 2008 Oct 1. PMID 18802077
    4. Downregulation of inflammatory microRNAs by Ig-like transcript 3 is essential for the differentiation of human CD8(+) T suppressor cells. Chang CC, et al. J Immunol, 2012 Apr 1. PMID 22387553
    5. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Lilrb4 ameliorates ileal injury in rats with hemorrhagic shock and suppresses the activation of NF-kappaB signaling pathway.
      Title: Lilrb4 ameliorates ileal injury in rats with hemorrhagic shock and suppresses the activation of NF-κB signaling pathway.
    2. Compared to mouse, the cytoplasmic domain of rat gp49B contains a third ITIM-like sequence
      Title: The rat orthologue to the inhibitory receptor gp49B is expressed by neutrophils and monocytes, but not by NK cells or mast cells.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables apolipoprotein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables fibronectin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signaling receptor inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transmembrane receptor protein tyrosine kinase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Fc receptor mediated inhibitory signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in immune response-regulating signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in interleukin-10-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mast cell activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of IP-10 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of T cell costimulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of T cell cytokine production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of T cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of activated T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of chemokine production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cytokine production involved in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cytotoxic T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of interleukin-1 beta production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of interleukin-10 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of interleukin-2 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of interleukin-5 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of miRNA transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of monocyte activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of osteoclast differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein localization to nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of signaling receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of type II interferon production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of CD8-positive, alpha-beta T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of T cell anergy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of regulatory T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in receptor internalization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tolerance induction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    leukocyte immunoglobulin like receptor B4
    Names
    glycoprotein 49b
    leukocyte immunoglobulin-like receptor, subfamily B, member 4
    leukocyte surface receptor

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013894.2 → NP_001013916.1  leukocyte immunoglobulin like receptor B4 isoform 3 precursor

      See identical proteins and their annotated locations for NP_001013916.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A0G2JVH3, E9PTH5, Q67EV2
      Related
      ENSRNOP00000030632.5, ENSRNOT00000038898.6
      Conserved Domains (1) summary
      cl11960
      Location:124 → 218
      Ig; Immunoglobulin domain

    2. NM_001419406.1 → NP_001406335.1  leukocyte immunoglobulin like receptor B4 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A0G2JVH3, Q67EV3
      Related
      ENSRNOP00000069484.1, ENSRNOT00000077186.3

    3. NM_001419407.1 → NP_001406336.1  leukocyte immunoglobulin like receptor B4 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6A469, A0A8I6GJM6
      Related
      ENSRNOP00000092281.1, ENSRNOT00000110970.2

    4. NM_001419408.1 → NP_001406337.1  leukocyte immunoglobulin like receptor B4 isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6A0J7
      Related
      ENSRNOP00000083730.1, ENSRNOT00000098988.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      78847685..78853294 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039103862.2 → XP_038959790.1  leukocyte immunoglobulin like receptor B4 isoform X3

      UniProtKB/TrEMBL
      A0A8I6A0J7
      Conserved Domains (2) summary
      cd00096
      Location:29 → 33
      Ig; Ig strand A [structural motif]
      cl11960
      Location:29 → 123
      Ig; Immunoglobulin domain

    2. XM_039103861.2 → XP_038959789.1  leukocyte immunoglobulin like receptor B4 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A095, A0A8I6A469
      Related
      ENSRNOP00000083948.1, ENSRNOT00000095592.2
      Conserved Domains (3) summary
      cd00096
      Location:124 → 128
      Ig; Ig strand A [structural motif]
      cd16843
      Location:28 → 116
      IgC2_D1_D2_LILR_KIR_like; Immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors, Natural killer inhibitory receptors (KIRs) and similar domains; member of Immunoglobulin Constant-2 set of IgSF domains
      cl11960
      Location:124 → 218
      Ig; Immunoglobulin domain

    3. XM_063283034.1 → XP_063139104.1  leukocyte immunoglobulin like receptor B4 isoform X6

    4. XM_063283032.1 → XP_063139102.1  leukocyte immunoglobulin like receptor B4 isoform X5

    5. XM_063283021.1 → XP_063139091.1  leukocyte immunoglobulin like receptor B4 isoform X1

      Related
      ENSRNOP00000087354.2, ENSRNOT00000109192.2

    6. XM_063283028.1 → XP_063139098.1  leukocyte immunoglobulin like receptor B4 isoform X4

    RNA

    1. XR_010064555.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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