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    Smdt1 single-pass membrane protein with aspartate-rich tail 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315166, updated on 9-Dec-2024

    Summary

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    Symbol
    Smdt1provided by RGD
    Full Name
    single-pass membrane protein with aspartate-rich tail 1provided by RGD
    Primary source
    RGD:1311310
    See related
    AllianceGenome:RGD:1311310
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311310
    Summary
    Predicted to enable channel activator activity and protein-macromolecule adaptor activity. Predicted to be involved in calcium import into the mitochondrion; cellular response to calcium ion starvation; and mitochondrial calcium ion homeostasis. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be part of uniplex complex. Predicted to be active in mitochondrial inner membrane. Orthologous to human SMDT1 (single-pass membrane protein with aspartate rich tail 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 664.3), Muscle (RPKM 520.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Smdt1 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (115742240..115745323)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (113862162..113865245)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (123578677..123581925)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene alpha-N-acetylgalactosaminidase Neighboring gene uncharacterized LOC134479948 Neighboring gene PH domain containing endocytic trafficking adaptor 2 Neighboring gene NADH:ubiquinone oxidoreductase subunit A6 Neighboring gene cytochrome P450, family 2, subfamily d, polypeptide 4 Neighboring gene uncharacterized LOC103692951

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The m-AAA Protease Associated with Neurodegeneration Limits MCU Activity in Mitochondria. König T, et al. Mol Cell, 2016 Oct 6. PMID 27642048
    2. Inactivation of Pde8b enhances memory, motor performance, and protects against age-induced motor coordination decay. Tsai LC, et al. Genes Brain Behav, 2012 Oct. PMID 22925203, Free PMC Article
    3. EMRE is an essential component of the mitochondrial calcium uniporter complex. Sancak Y, et al. Science, 2013 Dec 13. PMID 24231807, Free PMC Article
    4. Dual functions of a small regulatory subunit in the mitochondrial calcium uniporter complex. Tsai MF, et al. Elife, 2016 Apr 21. PMID 27099988, Free PMC Article
    5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables channel activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium import into the mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium import into the mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to calcium ion starvation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial calcium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of uniplex complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of uniplex complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    essential MCU regulator, mitochondrial

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399736.1 → NP_001386665.1  essential MCU regulator, mitochondrial

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A6HT67

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      115742240..115745323
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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