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    Tm4sf1 transmembrane 4 L six family member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 295061, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tm4sf1provided by RGD
    Official Full Name
    transmembrane 4 L six family member 1provided by RGD
    Primary source
    RGD:1309652
    See related
    EnsemblRapid:ENSRNOG00000015812 AllianceGenome:RGD:1309652
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to act upstream of or within blastocyst formation. Predicted to be located in plasma membrane. Predicted to be active in membrane. Orthologous to human TM4SF1 (transmembrane 4 L six family member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 138.6), Kidney (RPKM 77.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tm4sf1 in Genome Data Viewer
    Location:
    2q26
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (143606980..143616176, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (141456950..141466146, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (147382866..147392062, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene NSA2 ribosome biogenesis factor, pseudogene 23 Neighboring gene uncharacterized LOC120100824 Neighboring gene uncharacterized LOC134485620 Neighboring gene minichromosome maintenance complex component 4, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Tm4sf1-marked Endothelial Subpopulation Is Dysregulated in Pulmonary Arterial Hypertension. Hong J, et al. Am J Respir Cell Mol Biol, 2023 Apr. PMID 36252184, Free PMC Article
    2. Membrane topology of the L6 antigen and identification of the protein epitope recognized by the L6 monoclonal antibody. Marken JS, et al. J Biol Chem, 1994 Mar 11. PMID 7510285
    3. Towards Functional Annotation of the Preimplantation Transcriptome: An RNAi Screen in Mammalian Embryos. Cui W, et al. Sci Rep, 2016 Nov 21. PMID 27869233, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tm4sf1-marked Endothelial Subpopulation Is Dysregulated in Pulmonary Arterial Hypertension.
      Title: Tm4sf1-marked Endothelial Subpopulation Is Dysregulated in Pulmonary Arterial Hypertension.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within blastocyst formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane 4 L6 family member 1
    Names
    transmembrane 4 superfamily member 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106434.1 → NP_001099904.1  transmembrane 4 L6 family member 1

      See identical proteins and their annotated locations for NP_001099904.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474003
      UniProtKB/TrEMBL
      A6JVF9, D4ACP4
      Related
      ENSRNOP00000021536.5, ENSRNOT00000021535.7
      Conserved Domains (1) summary
      pfam05805
      Location:1 → 194
      L6_membrane; L6 membrane protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      143606980..143616176 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063281586.1 → XP_063137656.1  transmembrane 4 L6 family member 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZZ30
      Related
      ENSRNOP00000109282.1, ENSRNOT00000132709.1

    2. XM_039102015.2 → XP_038957943.1  transmembrane 4 L6 family member 1 isoform X2

      UniProtKB/TrEMBL
      A6JVG0
      Conserved Domains (1) summary
      pfam05805
      Location:4 → 138
      L6_membrane; L6 membrane protein
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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