Ano1 anoctamin 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ano1provided by RGD
Official Full Name: anoctamin 1provided by RGD
Primary source: RGD:1310786
See related: EnsemblRapid:ENSRNOG00000020865 AllianceGenome:RGD:1310786
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tmem16a
Summary: Enables intracellularly calcium-gated chloride channel activity; iodide transmembrane transporter activity; and signaling receptor binding activity. Involved in cellular response to peptide; chloride transmembrane transport; and iodide transport. Predicted to be located in apical plasma membrane; external side of plasma membrane; and nucleoplasm. Predicted to be active in glutamatergic synapse and presynaptic membrane. Human ortholog(s) of this gene implicated in Moyamoya disease. Orthologous to human ANO1 (anoctamin 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 135.7), Lung (RPKM 71.1) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q42

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (209180755..209329413, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (199751439..199900099, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (217754349..217902540, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Involvement of ANO1 currents in pacemaking of PDGFRalpha-positive specialised smooth muscle cells in rat caudal epididymis.
Title: Involvement of ANO1 currents in pacemaking of PDGFRα-positive specialised smooth muscle cells in rat caudal epididymis.
Spinal bestrophin-1 and anoctamin-1 channels have a pronociceptive role in the tactile allodynia induced by REM sleep deprivation in rats.
Title: Spinal bestrophin-1 and anoctamin-1 channels have a pronociceptive role in the tactile allodynia induced by REM sleep deprivation in rats.
The Role of TMEM16A/ERK/NK-1 Signaling in Dorsal Root Ganglia Neurons in the Development of Neuropathic Pain Induced by Spared Nerve Injury (SNI).
Title: The Role of TMEM16A/ERK/NK-1 Signaling in Dorsal Root Ganglia Neurons in the Development of Neuropathic Pain Induced by Spared Nerve Injury (SNI).
Local Ca(2+) signals couple activation of TRPV1 and ANO1 sensory ion channels.
Title: Local Ca(2+) signals couple activation of TRPV1 and ANO1 sensory ion channels.
ANO1 regulates cardiac fibrosis via ATI-mediated MAPK pathway.
Title: ANO1 regulates cardiac fibrosis via ATI-mediated MAPK pathway.
Coronary hypercontractility to acidosis owes to the greater activity of TMEM16A/ANO1 in the arterial smooth muscle cells.
Title: Coronary hypercontractility to acidosis owes to the greater activity of TMEM16A/ANO1 in the arterial smooth muscle cells.
Dual role of Ca(2+)-activated Cl(-) channel transmembrane member 16A in lipopolysaccharide-induced intestinal epithelial barrier dysfunction in vitro.
Title: Dual role of Ca(2+)-activated Cl(-) channel transmembrane member 16A in lipopolysaccharide-induced intestinal epithelial barrier dysfunction in vitro.
[Expression of ANO1 during cardiac fibroblasts differentiation and its electrophysiological characteristics as calcium-activated chloride channel protein].
Title: [Expression of ANO1 during cardiac fibroblasts differentiation and its electrophysiological characteristics as calcium-activated chloride channel protein].
TRPV4 and purinergic receptor signalling pathways are separately linked in airway epithelia to CFTR and TMEM16A chloride channels.
Title: TRPV4 and purinergic receptor signalling pathways are separately linked in airway epithelia to CFTR and TMEM16A chloride channels.
TMEM16A is implicated in the regulation of coronary flow and is altered in hypertension.
Title: TMEM16A is implicated in the regulation of coronary flow and is altered in hypertension.

Submit: New GeneRIF Correction See all GeneRIFs (32)

General gene information

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Markers

Tmem16a (e-PCR), detects polymorphism
- UniSTS:507438

D1Rat70 (e-PCR)
- UniSTS:118606

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium-activated cation channel activity	ISO Inferred from Sequence Orthology more info
enables chloride channel activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables intracellularly calcium-gated chloride channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables intracellularly calcium-gated chloride channel activity	IDA Inferred from Direct Assay more info	PubMed
enables intracellularly calcium-gated chloride channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables intracellularly calcium-gated chloride channel activity	ISO Inferred from Sequence Orthology more info
enables iodide transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables iodide transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
NOT enables phospholipid scramblase activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables voltage-gated chloride channel activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to heat	ISO Inferred from Sequence Orthology more info
involved_in cellular response to peptide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chloride transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in chloride transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chloride transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in chloride transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within chloride transport	ISO Inferred from Sequence Orthology more info
involved_in chloride transport	ISO Inferred from Sequence Orthology more info
NOT involved_in detection of mechanical stimulus involved in sensory perception of pain	ISO Inferred from Sequence Orthology more info
involved_in detection of temperature stimulus involved in sensory perception of pain	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of localization in cell	ISO Inferred from Sequence Orthology more info
involved_in glial cell projection elongation	ISO Inferred from Sequence Orthology more info
involved_in iodide transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in iodide transport	ISO Inferred from Sequence Orthology more info
involved_in monoatomic cation transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in mucus secretion	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
involved_in protein localization to membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of membrane potential	ISO Inferred from Sequence Orthology more info
involved_in trachea development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: anoctamin-1

Names: anoctamin 1, calcium activated chloride channel; transmembrane protein 16A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107564.1 → NP_001101034.1 anoctamin-1

See identical proteins and their annotated locations for NP_001101034.1

Status: PROVISIONAL

Source sequence(s)

CH473953

UniProtKB/TrEMBL

A0A0G2K052, A6HYG7, D4A915

Related

ENSRNOP00000028329.5, ENSRNOT00000028329.6

Conserved Domains (2) summary

pfam04547
Location:400 → 981

Anoctamin; Calcium-activated chloride channel

pfam16178
Location:112 → 397

Anoct_dimer; Dimerization domain of Ca+-activated chloride-channel, anoctamin