Gkn1 gastrokine 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gkn1provided by RGD
Official Full Name: gastrokine 1provided by RGD
Primary source: RGD:735014
See related: EnsemblRapid:ENSRNOG00000008838 AllianceGenome:RGD:735014
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Fov; Ca11; Amp18; foveolin
Summary: Predicted to enable growth factor activity. Predicted to be involved in regulation of cell population proliferation. Predicted to act upstream of or within positive regulation of cell population proliferation. Predicted to be located in extracellular region and secretory granule. Predicted to be active in extracellular space. Orthologous to human GKN1 (gastrokine 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Uterus (RPKM 1.4), Adrenal (RPKM 1.1) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4q34

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (121347417..121352705, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (119790101..119795389, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (119143070..119148358, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables growth factor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in secretory granule	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: gastrokine-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_198972.1 → NP_945323.1 gastrokine-1 precursor

See identical proteins and their annotated locations for NP_945323.1

Status: PROVISIONAL

Source sequence(s)

AY456958

UniProtKB/TrEMBL

F7ETE6, Q6SJV7

Related

ENSRNOP00000012218.6, ENSRNOT00000012218.7

Conserved Domains (1) summary

smart01039
Location:53 → 147

BRICHOS; The BRICHOS domain is found in a variety of proteins implicated in dementia, respiratory distress and cancer