Tyrp1 tyrosinase-related protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tyrp1provided by RGD
Official Full Name: tyrosinase-related protein 1provided by RGD
Primary source: RGD:1593266
See related: EnsemblRapid:ENSRNOG00000029318 AllianceGenome:RGD:1593266
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable protein homodimerization activity and tyrosinase activity. Predicted to be involved in melanocyte differentiation; melanosome organization; and positive regulation of melanin biosynthetic process. Predicted to act upstream of or within acetoacetic acid metabolic process; melanin metabolic process; and pigmentation. Predicted to be located in clathrin-coated endocytic vesicle membrane; endosome membrane; and melanosome membrane. Predicted to be active in melanosome. Human ortholog(s) of this gene implicated in oculocutaneous albinism; oculocutaneous albinism type III; and pigmentation disease. Orthologous to human TYRP1 (tyrosinase related protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 4.0), Kidney (RPKM 3.0) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q31

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (100327111..100345657)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (95280982..95299516)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (98387291..98406083)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TYRP1 Protects Against the Apoptosis and Oxidative Stress of Retinal Ganglion Cells by Binding to PMEL.
Title: TYRP1 Protects Against the Apoptosis and Oxidative Stress of Retinal Ganglion Cells by Binding to PMEL.

Submit: New GeneRIF Correction

General gene information

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Markers

D5Rat88 (e-PCR)
- UniSTS:118934

RH134304 (e-PCR)
- UniSTS:217586

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables tyrosinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within acetoacetic acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in melanin biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within melanin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in melanocyte differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within melanocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in melanosome organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within melanosome organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within pigmentation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of melanin biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in clathrin-coated endocytic vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in endosome membrane	ISO Inferred from Sequence Orthology more info
located_in intracellular vesicle	ISO Inferred from Sequence Orthology more info
is_active_in melanosome	IBA Inferred from Biological aspect of Ancestor more info
located_in melanosome	ISO Inferred from Sequence Orthology more info
located_in melanosome membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: 5,6-dihydroxyindole-2-carboxylic acid oxidase

Names: tyrosine phosphatase 1, same as B (Brown)

NP_001100134.1

EC 1.14.18.-

XP_063143435.1

EC 1.14.18.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.